Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2527540..2528197 Replicon chromosome
Accession NZ_CP093249
Organism Moellerella wisconsensis strain W18-2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MNY64_RS11280 Protein ID WP_047255277.1
Coordinates 2527540..2527950 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag MNY64_RS11285 Protein ID WP_047255278.1
Coordinates 2527931..2528197 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY64_RS11260 (MNY64_11265) 2522803..2524536 - 1734 WP_241543231.1 single-stranded-DNA-specific exonuclease RecJ -
MNY64_RS11265 (MNY64_11270) 2524545..2525237 - 693 WP_047255274.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MNY64_RS11270 (MNY64_11275) 2525262..2526173 - 912 WP_047255275.1 site-specific tyrosine recombinase XerD -
MNY64_RS11275 (MNY64_11280) 2526394..2526912 + 519 WP_047255276.1 flavodoxin FldB -
MNY64_RS11280 (MNY64_11285) 2527540..2527950 - 411 WP_047255277.1 protein YgfX Toxin
MNY64_RS11285 (MNY64_11290) 2527931..2528197 - 267 WP_047255278.1 FAD assembly factor SdhE Antitoxin
MNY64_RS11290 (MNY64_11295) 2528458..2529450 + 993 WP_241543232.1 tRNA-modifying protein YgfZ -
MNY64_RS11295 (MNY64_11300) 2529468..2530088 + 621 WP_241500862.1 HD domain-containing protein -
MNY64_RS11300 (MNY64_11305) 2530260..2533139 - 2880 WP_241543233.1 aminomethyl-transferring glycine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15525.49 Da        Isoelectric Point: 10.3270

>T237936 WP_047255277.1 NZ_CP093249:c2527950-2527540 [Moellerella wisconsensis]
VVLWKSNLSISWMAQLFSTCVHCVLGLVLLLAPWPTGNSIIWLPLLMVTIASWAKSQKNINKYKGIIVLTNGNKVQWKKN
EWSIITPPWCTRFGILLTLSALQGKPRKIKLWIAADAISEDDWRNLNQLLLQYPDI

Download         Length: 411 bp

>T237936 NZ_LR883012:675043-675357 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10681.11 Da        Isoelectric Point: 5.1391

>AT237936 WP_047255278.1 NZ_CP093249:c2528197-2527931 [Moellerella wisconsensis]
MDIDNKARIHWACRRGMRELDISIMPFFEHEYDGLNDNEKHQFIRLLECADPDLFNWLMNHGRPDDDELYHMIKLIQQRN
KDRGPVEI

Download         Length: 267 bp

>AT237936 NZ_LR883012:675354-675770 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References