Detailed information of TA system TA237936

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2527540..2528197
• Replicon: chromosome
• Accession: NZ_CP093249
• Organism: Moellerella wisconsensis strain W18-2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MNY64_RS11280
• Protein ID: WP_047255277.1
• Coordinates: 2527540..2527950 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: MNY64_RS11285
• Protein ID: WP_047255278.1
• Coordinates: 2527931..2528197 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY64_RS11260 (MNY64_11265)	2522803..2524536	-	1734	WP_241543231.1	single-stranded-DNA-specific exonuclease RecJ	-
MNY64_RS11265 (MNY64_11270)	2524545..2525237	-	693	WP_047255274.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MNY64_RS11270 (MNY64_11275)	2525262..2526173	-	912	WP_047255275.1	site-specific tyrosine recombinase XerD	-
MNY64_RS11275 (MNY64_11280)	2526394..2526912	+	519	WP_047255276.1	flavodoxin FldB	-
MNY64_RS11280 (MNY64_11285)	2527540..2527950	-	411	WP_047255277.1	protein YgfX	Toxin
MNY64_RS11285 (MNY64_11290)	2527931..2528197	-	267	WP_047255278.1	FAD assembly factor SdhE	Antitoxin
MNY64_RS11290 (MNY64_11295)	2528458..2529450	+	993	WP_241543232.1	tRNA-modifying protein YgfZ	-
MNY64_RS11295 (MNY64_11300)	2529468..2530088	+	621	WP_241500862.1	HD domain-containing protein	-
MNY64_RS11300 (MNY64_11305)	2530260..2533139	-	2880	WP_241543233.1	aminomethyl-transferring glycine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15525.49 Da
• Isoelectric Point: 10.3270

>T237936 WP_047255277.1 NZ_CP093249:c2527950-2527540 [Moellerella wisconsensis]
VVLWKSNLSISWMAQLFSTCVHCVLGLVLLLAPWPTGNSIIWLPLLMVTIASWAKSQKNINKYKGIIVLTNGNKVQWKKN
EWSIITPPWCTRFGILLTLSALQGKPRKIKLWIAADAISEDDWRNLNQLLLQYPDI

Nucleotide

• Length: 411 bp

>T237936 NZ_LR883012:675043-675357 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10681.11 Da
• Isoelectric Point: 5.1391

>AT237936 WP_047255278.1 NZ_CP093249:c2528197-2527931 [Moellerella wisconsensis]
MDIDNKARIHWACRRGMRELDISIMPFFEHEYDGLNDNEKHQFIRLLECADPDLFNWLMNHGRPDDDELYHMIKLIQQRN
KDRGPVEI

Nucleotide

• Length: 267 bp

>AT237936 NZ_LR883012:675354-675770 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA