Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2898849..2899488 Replicon chromosome
Accession NZ_CP093245
Organism Moellerella wisconsensis strain W51

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag MNY72_RS12980 Protein ID WP_269430900.1
Coordinates 2899264..2899488 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MNY72_RS12975 Protein ID WP_047256412.1
Coordinates 2898849..2899217 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY72_RS12950 (MNY72_12940) 2894050..2894811 - 762 WP_047256407.1 DNA polymerase III subunit epsilon -
MNY72_RS12955 (MNY72_12945) 2894868..2895335 + 468 WP_047256408.1 ribonuclease HI -
MNY72_RS12960 (MNY72_12950) 2895338..2896054 - 717 WP_047256409.1 methyltransferase domain-containing protein -
MNY72_RS12965 (MNY72_12955) 2896089..2896844 + 756 WP_047256410.1 hydroxyacylglutathione hydrolase -
MNY72_RS12970 (MNY72_12960) 2896916..2898271 + 1356 WP_047256411.1 murein transglycosylase D -
MNY72_RS12975 (MNY72_12965) 2898849..2899217 + 369 WP_047256412.1 Hha toxicity modulator TomB Antitoxin
MNY72_RS12980 (MNY72_12970) 2899264..2899488 + 225 WP_269430900.1 HHA domain-containing protein Toxin
MNY72_RS12990 (MNY72_12980) 2900248..2900709 - 462 WP_241541987.1 YbaY family lipoprotein -
MNY72_RS12995 (MNY72_12985) 2901106..2901969 + 864 WP_241501033.1 acyl-CoA thioesterase II -
MNY72_RS13000 (MNY72_12990) 2903034..2904317 - 1284 WP_047256416.1 ammonium transporter AmtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(15-71)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8977.32 Da        Isoelectric Point: 5.8622

>T237931 WP_269430900.1 NZ_CP093245:2899264-2899488 [Moellerella wisconsensis]
MNERQENMTKTDYLMRLRKCTTIETLERVIEKNKYELSDDELELFFSAADHRLAELTMNKLYDKIPASVWKYVR

Download         Length: 225 bp

>T237931 NZ_LR883008:128487-128648 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTAATATTCACACTCCTGACCCG
GAATCGTCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAGGTTACGGCAAGTTTGGCTTACGAATCCAGCGGTAAGT
AG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14371.20 Da        Isoelectric Point: 4.5817

>AT237931 WP_047256412.1 NZ_CP093245:2898849-2899217 [Moellerella wisconsensis]
MDEYSPRYYDTAELKYLCDSLNNDAILSLHKTKTHWINDLSSQQSTNLNELIEHVAAFFWKFKIKYPSERLVISLVDEYL
DETYNLFGSPLITLNEFSDWQKMNTHLIDELNNDLKCSVAKL

Download         Length: 369 bp

>AT237931 NZ_LR883008:128235-128434 [Escherichia coli]
CCCGTGAACTGGCTGAACGACCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGTGTGCAGGTATATGGGCTATGATGTG
CCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGCAGAAAGCCCCGT
AGTTAATTTTTCATTAACCCACGAGGCCCCCTGTATGTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References