Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 253382..253974 | Replicon | plasmid pW65-a |
| Accession | NZ_CP093243 | ||
| Organism | Moellerella wisconsensis strain W65 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | MNY66_RS17385 | Protein ID | WP_241501929.1 |
| Coordinates | 253382..253729 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | U5N340 |
| Locus tag | MNY66_RS17390 | Protein ID | WP_023159984.1 |
| Coordinates | 253729..253974 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNY66_RS17350 (MNY66_17350) | 248633..248902 | - | 270 | WP_048821758.1 | hypothetical protein | - |
| MNY66_RS17355 (MNY66_17355) | 249197..250150 | + | 954 | WP_166268230.1 | site-specific integrase | - |
| MNY66_RS17360 (MNY66_17360) | 250166..250810 | + | 645 | WP_241501926.1 | DUF4365 domain-containing protein | - |
| MNY66_RS17370 (MNY66_17370) | 251569..251775 | + | 207 | WP_241501927.1 | hypothetical protein | - |
| MNY66_RS17375 (MNY66_17375) | 251796..252362 | + | 567 | WP_241501928.1 | hypothetical protein | - |
| MNY66_RS17380 (MNY66_17380) | 252452..253399 | + | 948 | WP_140035165.1 | IS30 family transposase | - |
| MNY66_RS17385 (MNY66_17385) | 253382..253729 | - | 348 | WP_241501929.1 | endoribonuclease MazF | Toxin |
| MNY66_RS17390 (MNY66_17390) | 253729..253974 | - | 246 | WP_023159984.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| MNY66_RS17395 (MNY66_17395) | 254267..254890 | + | 624 | WP_023159958.1 | AAA family ATPase | - |
| MNY66_RS17400 (MNY66_17400) | 254999..255226 | + | 228 | WP_048821767.1 | plasmid partition protein ParG | - |
| MNY66_RS17405 (MNY66_17405) | 255324..255692 | - | 369 | WP_048821769.1 | hypothetical protein | - |
| MNY66_RS17410 (MNY66_17410) | 256453..257031 | - | 579 | WP_048822182.1 | hypothetical protein | - |
| MNY66_RS17415 (MNY66_17415) | 257040..257519 | - | 480 | WP_048821772.1 | Hcp family type VI secretion system effector | - |
| MNY66_RS17420 (MNY66_17420) | 257800..258192 | - | 393 | WP_048821774.1 | hypothetical protein | - |
| MNY66_RS17425 (MNY66_17425) | 258202..258624 | - | 423 | WP_048821775.1 | hypothetical protein | - |
| MNY66_RS17430 (MNY66_17430) | 258617..258961 | - | 345 | WP_023159966.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(H) / aadA14 / dfrA1 / ant(3'')-Ia / sul3 / blaCTX-M-1 / mph(A) / aph(3')-Ia | - | 1..345391 | 345391 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12841.66 Da Isoelectric Point: 7.6689
>T237927 WP_241501929.1 NZ_CP093243:c253729-253382 [Moellerella wisconsensis]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIRRIQVRSATLSRLS
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIRRIQVRSATLSRLS
Download Length: 348 bp
>T237927 NZ_LR883006:c4778314-4778003 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8786.20 Da Isoelectric Point: 5.0351
>AT237927 WP_023159984.1 NZ_CP093243:c253974-253729 [Moellerella wisconsensis]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I
Download Length: 246 bp
>AT237927 NZ_LR883006:c4778002-4777712 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|