Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2920917..2921556 Replicon chromosome
Accession NZ_CP093242
Organism Moellerella wisconsensis strain W65

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag MNY66_RS12840 Protein ID WP_269430900.1
Coordinates 2921332..2921556 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MNY66_RS12835 Protein ID WP_047256412.1
Coordinates 2920917..2921285 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY66_RS12810 (MNY66_12810) 2916118..2916879 - 762 WP_047256407.1 DNA polymerase III subunit epsilon -
MNY66_RS12815 (MNY66_12815) 2916936..2917403 + 468 WP_047256408.1 ribonuclease HI -
MNY66_RS12820 (MNY66_12820) 2917406..2918122 - 717 WP_241501032.1 methyltransferase domain-containing protein -
MNY66_RS12825 (MNY66_12825) 2918157..2918912 + 756 WP_047256410.1 hydroxyacylglutathione hydrolase -
MNY66_RS12830 (MNY66_12830) 2918984..2920339 + 1356 WP_047256411.1 murein transglycosylase D -
MNY66_RS12835 (MNY66_12835) 2920917..2921285 + 369 WP_047256412.1 Hha toxicity modulator TomB Antitoxin
MNY66_RS12840 (MNY66_12840) 2921332..2921556 + 225 WP_269430900.1 HHA domain-containing protein Toxin
MNY66_RS12850 (MNY66_12850) 2922316..2922777 - 462 WP_047256414.1 YbaY family lipoprotein -
MNY66_RS12855 (MNY66_12855) 2923174..2924037 + 864 WP_241501033.1 acyl-CoA thioesterase II -
MNY66_RS12860 (MNY66_12860) 2925102..2926385 - 1284 WP_047256416.1 ammonium transporter AmtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2911012..2940593 29581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(15-71)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8977.32 Da        Isoelectric Point: 5.8622

>T237922 WP_269430900.1 NZ_CP093242:2921332-2921556 [Moellerella wisconsensis]
MNERQENMTKTDYLMRLRKCTTIETLERVIEKNKYELSDDELELFFSAADHRLAELTMNKLYDKIPASVWKYVR

Download         Length: 225 bp

>T237922 NZ_LR883006:3681729-3682271 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14371.20 Da        Isoelectric Point: 4.5817

>AT237922 WP_047256412.1 NZ_CP093242:2920917-2921285 [Moellerella wisconsensis]
MDEYSPRYYDTAELKYLCDSLNNDAILSLHKTKTHWINDLSSQQSTNLNELIEHVAAFFWKFKIKYPSERLVISLVDEYL
DETYNLFGSPLITLNEFSDWQKMNTHLIDELNNDLKCSVAKL

Download         Length: 369 bp

>AT237922 NZ_LR883006:3681434-3681745 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References