Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 51829..52403 Replicon plasmid pW49-2-a
Accession NZ_CP093240
Organism Escherichia marmotae strain W49-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A449CCI1
Locus tag MNY74_RS24800 Protein ID WP_000604347.1
Coordinates 52029..52403 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MNY74_RS24795 Protein ID WP_097468730.1
Coordinates 51829..52032 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY74_RS24765 (46967) 46967..47746 + 780 Protein_67 DUF4942 domain-containing protein -
MNY74_RS24770 (47791) 47791..48042 - 252 WP_061361338.1 helix-turn-helix transcriptional regulator -
MNY74_RS24775 (48495) 48495..48641 + 147 WP_157921632.1 hypothetical protein -
MNY74_RS24780 (48780) 48780..49262 - 483 WP_241556897.1 hypothetical protein -
MNY74_RS24785 (49365) 49365..49700 + 336 WP_050940568.1 plasmid mobilization protein MobA -
MNY74_RS24790 (49784) 49784..51718 + 1935 WP_241556898.1 relaxase/mobilization nuclease domain-containing protein -
MNY74_RS24795 (51829) 51829..52032 + 204 WP_097468730.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MNY74_RS24800 (52029) 52029..52403 + 375 WP_000604347.1 PIN domain-containing protein Toxin
MNY74_RS24805 (52937) 52937..53206 - 270 Protein_75 type II toxin-antitoxin system toxin YacB -
MNY74_RS24810 (53206) 53206..53475 - 270 WP_097468729.1 type II toxin-antitoxin system antitoxin YacA -
MNY74_RS24815 (53843) 53843..54073 - 231 Protein_77 hypothetical protein -
MNY74_RS24820 (54103) 54103..54234 - 132 Protein_78 transposase -
MNY74_RS25645 (55094) 55094..55315 + 222 WP_275943200.1 PapB/FocB family fimbrial expression transcriptional regulator -
MNY74_RS24830 (55654) 55654..56172 + 519 WP_105289590.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeC / faeD / faeE / faeF / faeH / faeI / faeJ / papC / papH / papH / papC 1..118621 118621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.35 Da        Isoelectric Point: 7.3233

>T237919 WP_000604347.1 NZ_CP093240:52029-52403 [Escherichia marmotae]
MILVDTSVWVDHFKNKNDTLIQLLQSDFVLMHPMILAEIACGTPPAPRQRTLSDLDLLPKSHQATITEVLAFIENEKLFG
LGCGLVDITLLASTRITPGAKIWTLDKRLSRLAKRLNVEYQPVH

Download         Length: 375 bp

>T237919 NZ_LR883006:2788335-2788442 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7369.43 Da        Isoelectric Point: 4.9987

>AT237919 WP_097468730.1 NZ_CP093240:51829-52032 [Escherichia marmotae]
MRTTVTIDDALYAQALEMADPGMDKSDIFREAVKTFIRVQAAKRLASLGGTAPDMEITPRRRGDVAE

Download         Length: 204 bp

>AT237919 NZ_LR883006:c2788285-2788222 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449CCI1

Antitoxin

Source ID Structure

References