Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 32809..33344 Replicon plasmid pW49-2-a
Accession NZ_CP093240
Organism Escherichia marmotae strain W49-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MNY74_RS24645 Protein ID WP_134901167.1
Coordinates 33057..33344 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag MNY74_RS24640 Protein ID WP_001132900.1
Coordinates 32809..33060 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY74_RS24620 (28399) 28399..28923 - 525 WP_181475208.1 fimbrial protein -
MNY74_RS24625 (29169) 29169..29477 - 309 WP_181475198.1 adhesin biosynthesis transcription regulatory family protein -
MNY74_RS24630 (30086) 30086..32510 - 2425 Protein_40 Tn3 family transposase -
MNY74_RS24635 (32527) 32527..32664 + 138 Protein_41 recombinase family protein -
MNY74_RS24640 (32809) 32809..33060 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MNY74_RS24645 (33057) 33057..33344 + 288 WP_134901167.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNY74_RS24650 (33536) 33536..33655 + 120 Protein_44 helix-turn-helix transcriptional regulator -
MNY74_RS24655 (33798) 33798..34349 - 552 WP_052980227.1 plasmid partitioning/stability family protein -
MNY74_RS24660 (34361) 34361..35332 - 972 WP_163516419.1 plasmid segregation protein ParM -
MNY74_RS24665 (35509) 35509..35793 + 285 WP_193803165.1 hypothetical protein -
MNY74_RS24670 (35870) 35870..36553 + 684 WP_193803162.1 DNA methylase -
MNY74_RS24675 (36554) 36554..36775 + 222 WP_001558391.1 hypothetical protein -
MNY74_RS24680 (36756) 36756..37223 + 468 WP_236943025.1 DUF1380 family protein -
MNY74_RS24685 (37632) 37632..38057 + 426 WP_241556894.1 antirestriction protein -
MNY74_RS24690 (38106) 38106..38297 + 192 WP_021548775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeC / faeD / faeE / faeF / faeH / faeI / faeJ / papC / papH / papH / papC 1..118621 118621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11087.07 Da        Isoelectric Point: 10.4701

>T237918 WP_134901167.1 NZ_CP093240:33057-33344 [Escherichia marmotae]
MTYTVKFRDDALKEWLKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T237918 NZ_LR883006:2787800-2787907 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT237918 WP_001132900.1 NZ_CP093240:32809-33060 [Escherichia marmotae]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT237918 NZ_LR883006:c2787747-2787686 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References