Detailed information of TA system TA237909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2418402..2419040
• Replicon: chromosome
• Accession: NZ_CP093239
• Organism: Escherichia marmotae strain W49-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7U9DHD1
• Locus tag: MNY74_RS11400
• Protein ID: WP_000813795.1
• Coordinates: 2418864..2419040 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MNY74_RS11395
• Protein ID: WP_077627724.1
• Coordinates: 2418402..2418818 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY74_RS11375 (2413557)	2413557..2414498	-	942	WP_001516417.1	ABC transporter permease	-
MNY74_RS11380 (2414499)	2414499..2415512	-	1014	WP_241556844.1	ABC transporter ATP-binding protein	-
MNY74_RS11385 (2415530)	2415530..2416675	-	1146	WP_000047463.1	ABC transporter substrate-binding protein	-
MNY74_RS11390 (2416914)	2416914..2418323	-	1410	WP_016248716.1	PLP-dependent aminotransferase family protein	-
MNY74_RS11395 (2418402)	2418402..2418818	-	417	WP_077627724.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
MNY74_RS11400 (2418864)	2418864..2419040	-	177	WP_000813795.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
MNY74_RS11405 (2419262)	2419262..2419492	+	231	WP_000494240.1	DUF2554 family protein	-
MNY74_RS11410 (2419586)	2419586..2421547	-	1962	WP_241556859.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
MNY74_RS11415 (2421620)	2421620..2422156	-	537	WP_000429073.1	XRE family transcriptional regulator	-
MNY74_RS11420 (2422248)	2422248..2423420	+	1173	WP_241556845.1	benzoate/H(+) symporter BenE family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6747.80 Da
• Isoelectric Point: 11.5666

>T237909 WP_000813795.1 NZ_CP093239:c2419040-2418864 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T237909 NZ_LR883006:1392206-1392604 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGAGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15250.62 Da
• Isoelectric Point: 4.5908

>AT237909 WP_077627724.1 NZ_CP093239:c2418818-2418402 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT237909 NZ_LR883006:1391979-1392206 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Toxin

• AlphaFold DB: A0A7U9DHD1