Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1330130..1330748 Replicon chromosome
Accession NZ_CP093239
Organism Escherichia marmotae strain W49-2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MNY74_RS06280 Protein ID WP_001280991.1
Coordinates 1330130..1330348 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag MNY74_RS06285 Protein ID WP_000344801.1
Coordinates 1330353..1330748 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY74_RS06245 (1325424) 1325424..1325996 + 573 WP_000779815.1 YbaY family lipoprotein -
MNY74_RS06250 (1326027) 1326027..1326338 - 312 WP_000409903.1 MGMT family protein -
MNY74_RS06260 (1326718) 1326718..1327071 + 354 WP_000878149.1 DUF1428 domain-containing protein -
MNY74_RS06265 (1327108) 1327108..1328658 - 1551 WP_001515896.1 EAL domain-containing protein -
MNY74_RS06270 (1328822) 1328822..1329292 - 471 WP_001515897.1 YlaC family protein -
MNY74_RS06275 (1329407) 1329407..1329958 - 552 WP_000102537.1 maltose O-acetyltransferase -
MNY74_RS06280 (1330130) 1330130..1330348 - 219 WP_001280991.1 HHA domain-containing protein Toxin
MNY74_RS06285 (1330353) 1330353..1330748 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
MNY74_RS06290 (1331305) 1331305..1334454 - 3150 WP_001132495.1 efflux RND transporter permease AcrB -
MNY74_RS06295 (1334477) 1334477..1335670 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T237898 WP_001280991.1 NZ_CP093239:c1330348-1330130 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T237898 NZ_LR882998:151619-151777 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT237898 WP_000344801.1 NZ_CP093239:c1330748-1330353 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp

>AT237898 NZ_LR882998:151508-151573 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References