Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1881153..1881988 Replicon chromosome
Accession NZ_CP093226
Organism Escherichia coli strain EC-16-35

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag MNY24_RS08915 Protein ID WP_000854761.1
Coordinates 1881153..1881530 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag MNY24_RS08920 Protein ID WP_001295723.1
Coordinates 1881620..1881988 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY24_RS08875 (1876542) 1876542..1876808 - 267 WP_087757644.1 EutP/PduV family microcompartment system protein -
MNY24_RS08880 (1877178) 1877178..1877567 - 390 WP_001445118.1 IS110 family transposase -
MNY24_RS08885 (1877756) 1877756..1877980 - 225 Protein_1750 transposase -
MNY24_RS08890 (1878061) 1878061..1878465 + 405 WP_000839179.1 transposase -
MNY24_RS08895 (1878462) 1878462..1878809 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
MNY24_RS08900 (1878858) 1878858..1880397 + 1540 Protein_1753 IS66-like element ISEc22 family transposase -
MNY24_RS08905 (1880828) 1880828..1880908 - 81 Protein_1754 hypothetical protein -
MNY24_RS08910 (1881008) 1881008..1881156 - 149 Protein_1755 DUF5983 family protein -
MNY24_RS08915 (1881153) 1881153..1881530 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
MNY24_RS08920 (1881620) 1881620..1881988 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MNY24_RS08925 (1882151) 1882151..1882372 - 222 WP_000692341.1 DUF987 domain-containing protein -
MNY24_RS08930 (1882435) 1882435..1882911 - 477 WP_001186774.1 RadC family protein -
MNY24_RS08935 (1882927) 1882927..1883400 - 474 WP_000855059.1 antirestriction protein -
MNY24_RS08940 (1883742) 1883742..1884560 - 819 WP_001234729.1 DUF932 domain-containing protein -
MNY24_RS08945 (1884678) 1884678..1884873 - 196 Protein_1762 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T237857 WP_000854761.1 NZ_CP093226:c1881530-1881153 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T237857 NZ_LR882979:60079-60231 [Escherichia coli]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGTTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT237857 WP_001295723.1 NZ_CP093226:c1881988-1881620 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT237857 NZ_LR882979:c60029-59967 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References