237849

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1931158..1931628 Replicon chromosome
Accession NZ_CP093222
Organism Staphylococcus epidermidis strain CICARIA

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MMZ11_RS09195 Protein ID WP_001829569.1
Coordinates 1931440..1931628 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MMZ11_RS09190 Protein ID WP_002438963.1
Coordinates 1931158..1931415 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ11_RS09150 (MMZ11_09150) 1926522..1927238 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MMZ11_RS09155 (MMZ11_09155) 1927399..1927821 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MMZ11_RS09160 (MMZ11_09160) 1928005..1928160 - 156 WP_001829648.1 hypothetical protein -
MMZ11_RS09165 (MMZ11_09165) 1928172..1928359 - 188 Protein_1755 hypothetical protein -
MMZ11_RS09170 (MMZ11_09170) 1928746..1929246 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MMZ11_RS09175 (MMZ11_09175) 1929517..1930104 - 588 WP_001829615.1 histidine phosphatase family protein -
MMZ11_RS09180 (MMZ11_09180) 1930318..1930554 + 237 WP_002457224.1 hypothetical protein -
MMZ11_RS09185 (MMZ11_09185) 1930546..1930749 - 204 WP_001829671.1 sterile alpha motif-like domain-containing protein -
MMZ11_RS09190 (MMZ11_09190) 1931158..1931415 + 258 WP_002438963.1 hypothetical protein Antitoxin
MMZ11_RS09195 (MMZ11_09195) 1931440..1931628 + 189 WP_001829569.1 hypothetical protein Toxin
MMZ11_RS09200 (MMZ11_09200) 1931818..1932372 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MMZ11_RS09205 (MMZ11_09205) 1932432..1932665 - 234 WP_001829664.1 hypothetical protein -
MMZ11_RS09210 (MMZ11_09210) 1932950..1933696 + 747 WP_001829580.1 poly-gamma-glutamate hydrolase family protein -
MMZ11_RS09215 (MMZ11_09215) 1933795..1934079 + 285 WP_001829635.1 hypothetical protein -
MMZ11_RS09220 (MMZ11_09220) 1934103..1934327 + 225 WP_001829613.1 hypothetical protein -
MMZ11_RS09225 (MMZ11_09225) 1934948..1935148 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1928005..1928160 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T237849 WP_001829569.1 NZ_CP093222:1931440-1931628 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T237849 NZ_LR882978:2847526-2847633 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT237849 WP_002438963.1 NZ_CP093222:1931158-1931415 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT237849 NZ_LR882978:c2847473-2847412 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References