237846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 768950..769459 Replicon chromosome
Accession NZ_CP093222
Organism Staphylococcus epidermidis strain CICARIA

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MMZ11_RS03680 Protein ID WP_001829980.1
Coordinates 769250..769459 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MMZ11_RS03675 Protein ID WP_001829893.1
Coordinates 768950..769243 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ11_RS03650 (MMZ11_03650) 763958..764746 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MMZ11_RS03655 (MMZ11_03655) 764752..765390 + 639 WP_002505076.1 thiamine phosphate synthase -
MMZ11_RS03660 (MMZ11_03660) 765479..766351 + 873 WP_002470121.1 membrane protein insertase YidC -
MMZ11_RS03665 (MMZ11_03665) 766457..767110 - 654 WP_001829983.1 HD domain-containing protein -
MMZ11_RS03670 (MMZ11_03670) 767292..768776 - 1485 WP_002457116.1 cardiolipin synthase -
MMZ11_RS03675 (MMZ11_03675) 768950..769243 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MMZ11_RS03680 (MMZ11_03680) 769250..769459 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MMZ11_RS03685 (MMZ11_03685) 769602..769739 + 138 WP_001829949.1 Lmo0850 family protein -
MMZ11_RS03690 (MMZ11_03690) 769838..771049 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
MMZ11_RS03695 (MMZ11_03695) 771440..772513 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MMZ11_RS03700 (MMZ11_03700) 772525..773880 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237846 WP_001829980.1 NZ_CP093222:769250-769459 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237846 NZ_LR882978:2177913-2178016 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237846 WP_001829893.1 NZ_CP093222:768950-769243 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237846 NZ_LR882978:c2178054-2177783 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References