Detailed information of TA system TA237844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 4501885..4502503
• Replicon: chromosome
• Accession: NZ_CP093221
• Organism: Escherichia coli strain ER2683

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: MNV48_RS21815
• Protein ID: WP_001290581.1
• Coordinates: 4502285..4502503 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: S1PTH5
• Locus tag: MNV48_RS21810
• Protein ID: WP_000344800.1
• Coordinates: 4501885..4502259 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNV48_RS21800 (4496974)	4496974..4498167	+	1194	WP_001295324.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MNV48_RS21805 (4498190)	4498190..4501339	+	3150	WP_001132469.1	efflux RND transporter permease AcrB	-
MNV48_RS21810 (4501885)	4501885..4502259	+	375	WP_000344800.1	Hha toxicity modulator TomB	Antitoxin
MNV48_RS21815 (4502285)	4502285..4502503	+	219	WP_001290581.1	HHA domain-containing protein	Toxin
MNV48_RS21820 (4502675)	4502675..4503226	+	552	WP_000102564.1	maltose O-acetyltransferase	-
MNV48_RS21825 (4503342)	4503342..4503812	+	471	WP_000136192.1	YlaC family protein	-
MNV48_RS21830 (4503976)	4503976..4505526	+	1551	WP_001310610.1	cyclic-guanylate-specific phosphodiesterase PdeB	-
MNV48_RS21835 (4505568)	4505568..4505921	-	354	WP_000878140.1	DUF1428 domain-containing protein	-
MNV48_RS21845 (4506300)	4506300..4506611	+	312	WP_000409911.1	MGMT family protein	-
MNV48_RS21850 (4506642)	4506642..4507214	-	573	WP_000779842.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8678.06 Da
• Isoelectric Point: 8.9008

>T237844 WP_001290581.1 NZ_CP093221:4502285-4502503 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T237844 NZ_LR882978:1984475-1984726 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14557.39 Da
• Isoelectric Point: 4.7395

>AT237844 WP_000344800.1 NZ_CP093221:4501885-4502259 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Nucleotide

• Length: 375 bp

>AT237844 NZ_LR882978:1984723-1984977 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9QBQ5