Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3493207..3493845 Replicon chromosome
Accession NZ_CP093221
Organism Escherichia coli strain ER2683

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag MNV48_RS16930 Protein ID WP_000813794.1
Coordinates 3493669..3493845 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MNV48_RS16925 Protein ID WP_001270286.1
Coordinates 3493207..3493623 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNV48_RS16905 (3488359) 3488359..3489300 - 942 WP_001251304.1 ABC transporter permease -
MNV48_RS16910 (3489301) 3489301..3490314 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
MNV48_RS16915 (3490332) 3490332..3491477 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
MNV48_RS16920 (3491722) 3491722..3493128 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
MNV48_RS16925 (3493207) 3493207..3493623 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MNV48_RS16930 (3493669) 3493669..3493845 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MNV48_RS16935 (3494067) 3494067..3494297 + 231 WP_000494244.1 YncJ family protein -
MNV48_RS16940 (3494389) 3494389..3496350 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MNV48_RS16945 (3496423) 3496423..3496959 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MNV48_RS16950 (3497051) 3497051..3498226 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T237843 WP_000813794.1 NZ_CP093221:c3493845-3493669 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T237843 NZ_LR882978:1458432-1458830 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT237843 WP_001270286.1 NZ_CP093221:c3493623-3493207 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT237843 NZ_LR882978:1458205-1458432 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References