Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2923428..2924259 Replicon chromosome
Accession NZ_CP093221
Organism Escherichia coli strain ER2683

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag MNV48_RS14010 Protein ID WP_000854814.1
Coordinates 2923428..2923802 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag MNV48_RS14015 Protein ID WP_001285584.1
Coordinates 2923891..2924259 (-) Length 123 a.a.

Genomic Context

MNV48_RS13970MNV48_RS13975MNV48_RS13980MNV48_RS13985MNV48_RS13995MNV48_RS13990MNV48_RS14000MNV48_RS14005MNV48_RS14010MNV48_RS14015MNV48_RS14020MNV48_RS14025MNV48_RS14030
Location: 2918824..2919990 (1167 bp)
Type: Others
Protein ID: WP_000830156.1
Location: 2920109..2920582 (474 bp)
Type: Others
Protein ID: WP_001105415.1
Location: 2920780..2921838 (1059 bp)
Type: Others
Protein ID: WP_001200891.1
Location: 2922010..2922339 (330 bp)
Type: Others
Protein ID: WP_000450409.1
Location: 2922694..2922822 (129 bp)
Type: Others
Protein ID: Protein_2731
Location: 2922440..2922574 (135 bp)
Type: Others
Protein ID: WP_001297944.1
Location: 2923111..2923191 (81 bp)
Type: Others
Protein ID: Protein_2732
Location: 2923237..2923431 (195 bp)
Type: Others
Protein ID: WP_000988600.1
Location: 2923428..2923802 (375 bp)
Type: Toxin
Protein ID: WP_000854814.1
Location: 2923891..2924259 (369 bp)
Type: Antitoxin
Protein ID: WP_001285584.1
Location: 2924333..2924554 (222 bp)
Type: Others
Protein ID: WP_000692323.1
Location: 2924617..2925063 (447 bp)
Type: Others
Protein ID: WP_000187523.1
Location: 2925060..2926592 (1533 bp)
Type: Others
Protein ID: WP_001350525.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNV48_RS13970 (2918824)2918824..2919990+1167WP_000830156.1serine-type D-Ala-D-Ala carboxypeptidase DacD-
MNV48_RS13975 (2920109)2920109..2920582+474WP_001105415.1DNA gyrase inhibitor SbmC-
MNV48_RS13980 (2920780)2920780..2921838+1059WP_001200891.1FUSC family protein-
MNV48_RS13985 (2922010)2922010..2922339+330WP_000450409.1DUF496 family protein-
MNV48_RS13990 (2922440)2922440..2922574-135WP_001297944.1EutP/PduV family microcompartment system protein-
MNV48_RS13995 (2922694)2922694..2922822+129Protein_2731transposase domain-containing protein-
MNV48_RS14000 (2923111)2923111..2923191-81Protein_2732hypothetical protein-
MNV48_RS14005 (2923237)2923237..2923431-195WP_000988600.1DUF5983 family protein-
MNV48_RS14010 (2923428)2923428..2923802-375WP_000854814.1type IV toxin-antitoxin system cytoskeleton-binding toxin CbtAToxin
MNV48_RS14015 (2923891)2923891..2924259-369WP_001285584.1type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeAAntitoxin
MNV48_RS14020 (2924333)2924333..2924554-222WP_000692323.1DUF987 domain-containing protein-
MNV48_RS14025 (2924617)2924617..2925063-447WP_000187523.1RadC family protein-
MNV48_RS14030 (2925060)2925060..2926592-1533WP_001350525.1protein YeeR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T237832 WP_000854814.1 NZ_CP093221:c2923802-2923428 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T237832 NZ_LR882974:c33708-33502 [Escherichia coli]
ATGAAGTACTTGAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATACCCTTATTGG
GTTGCTCGCCGTGTGTGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT237832 WP_001285584.1 NZ_CP093221:c2924259-2923891 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT237832 NZ_LR882974:33700-33756 [Escherichia coli]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829FY50

Antitoxin

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Source
ID
Structure
PDB2H28
AlphaFold DBA0A1M2E8G6

References