Detailed information of TA system TA237821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 469649..470463
• Replicon: chromosome
• Accession: NZ_CP093221
• Organism: Escherichia coli strain ER2683

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: MNV48_RS02345
• Protein ID: WP_001054376.1
• Coordinates: 469649..469906 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: MNV48_RS02350
• Protein ID: WP_001309181.1
• Coordinates: 469918..470463 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNV48_RS02320 (464937)	464937..466043	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
MNV48_RS02325 (466108)	466108..467088	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
MNV48_RS02330 (467198)	467198..467403	+	206	Protein_456	HNH endonuclease	-
MNV48_RS02335 (467671)	467671..468911	-	1241	Protein_457	helicase YjhR	-
MNV48_RS02340 (469027)	469027..469158	+	132	WP_001309182.1	hypothetical protein	-
MNV48_RS02345 (469649)	469649..469906	+	258	WP_001054376.1	YjhX family toxin	Toxin
MNV48_RS02350 (469918)	469918..470463	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
MNV48_RS02355 (470519)	470519..471265	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
MNV48_RS02360 (471434)	471434..471652	+	219	Protein_462	hypothetical protein	-
MNV48_RS02365 (471690)	471690..471806	+	117	Protein_463	VOC family protein	-
MNV48_RS02370 (472051)	472051..473172	+	1122	WP_000010829.1	M42 family metallopeptidase	-
MNV48_RS02375 (473169)	473169..473447	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
MNV48_RS02380 (473459)	473459..474772	+	1314	WP_000460842.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimH / fimG / fimF / fimD / fimC / fimI / fimA / fimE / fimB	445268..478687	33419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T237821 WP_001054376.1 NZ_CP093221:469649-469906 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T237821 NZ_LR882973:925544-925951 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT237821 WP_001309181.1 NZ_CP093221:469918-470463 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT237821 NZ_LR882973:925297-925563 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8