Detailed information of TA system TA237812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 937893..938422
• Replicon: chromosome
• Accession: NZ_CP093217
• Organism: Staphylococcus edaphicus strain CCM 8731

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MNY58_RS04320
• Protein ID: WP_099091308.1
• Coordinates: 938060..938422 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A1D4YKY9
• Locus tag: MNY58_RS04315
• Protein ID: WP_017722121.1
• Coordinates: 937893..938063 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY58_RS04290 (MNY58_04290)	933626..934105	+	480	WP_099091313.1	PH domain-containing protein	-
MNY58_RS04295 (MNY58_04295)	934098..935643	+	1546	Protein_848	PH domain-containing protein	-
MNY58_RS04300 (MNY58_04300)	935636..936136	+	501	WP_099091311.1	PH domain-containing protein	-
MNY58_RS04305 (MNY58_04305)	936198..936548	+	351	WP_099091310.1	holo-ACP synthase	-
MNY58_RS04310 (MNY58_04310)	936657..937805	+	1149	WP_099091309.1	alanine racemase	-
MNY58_RS04315 (MNY58_04315)	937893..938063	+	171	WP_017722121.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MNY58_RS04320 (MNY58_04320)	938060..938422	+	363	WP_099091308.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MNY58_RS04325 (MNY58_04325)	938770..939771	+	1002	WP_249740171.1	PP2C family protein-serine/threonine phosphatase	-
MNY58_RS04330 (MNY58_04330)	939850..940176	+	327	WP_099091306.1	anti-sigma factor antagonist	-
MNY58_RS04335 (MNY58_04335)	940178..940660	+	483	WP_099091305.1	anti-sigma B factor RsbW	-
MNY58_RS04340 (MNY58_04340)	940635..941405	+	771	Protein_857	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13481.67 Da
• Isoelectric Point: 10.3173

>T237812 WP_099091308.1 NZ_CP093217:938060-938422 [Staphylococcus edaphicus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHNIRGHKS

Nucleotide

• Length: 363 bp

>T237812 NZ_LR882967:2652801-2653142 [Planktothrix pseudagardhii]
ATGAAGATTTGGATCGATGCTCAACTGCCGCCCACACTGGCAAATTGGCTAACAGAAACCTTTGGGTTAGAAGCGAGTGC
ATTGCGAGATTTAGAACTTCGGGATGCTCAAGATCTGGAAATTTTTGAAGCAGCACGATCCGAAAATGTTGTGATTATGA
CGAAAGACAGTGACTTCATCGACTTGGTATGTCGTTTAGGATCGCCTCCTCAAATTTTGTGGCTAACTTGTGGTAATGTT
ACTAACCGTAACTTGCGACAATTGTTGACTGCTACTTTTCCTGATGCGTTAGAGCAATTACGTCAAGGAGAAATGATTGT
AGAAATTACTAACACTCCTTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6305.92 Da
• Isoelectric Point: 4.0121

>AT237812 WP_017722121.1 NZ_CP093217:937893-938063 [Staphylococcus edaphicus]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Nucleotide

• Length: 171 bp

>AT237812 NZ_LR882967:2652571-2652804 [Planktothrix pseudagardhii]
ATGAATTTAACGACTGGCTTGCTAAACCGTATTACTCAAACTCCAGGTCAATGTGGTGGTCGTCCTTGTATTCGAGGGAT
GCGAATTCGAGTCACTGATATTTTAGAAATGTTGGCGGAAAATGTTAGCATTACTGAAATTTTAGAAGACTTCCCGGATT
TGGAATTAGCAGATATTCAAGCTTGTTTGCTGTTTGCCGCACGACGCACTGATTTTCCTAGACTAACAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1D4YKY9