Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 926292..926806 Replicon chromosome
Accession NZ_CP093217
Organism Staphylococcus edaphicus strain CCM 8731

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MNY58_RS04260 Protein ID WP_099091319.1
Coordinates 926600..926806 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MNY58_RS04255 Protein ID WP_099091320.1
Coordinates 926292..926585 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY58_RS04230 (MNY58_04230) 921429..922220 + 792 WP_099091327.1 hydroxyethylthiazole kinase -
MNY58_RS04235 (MNY58_04235) 922220..922858 + 639 WP_099091324.1 thiamine phosphate synthase -
MNY58_RS04240 (MNY58_04240) 922946..923815 + 870 WP_099091323.1 membrane protein insertase YidC -
MNY58_RS04245 (MNY58_04245) 923903..924550 - 648 WP_099091322.1 HD domain-containing protein -
MNY58_RS04250 (MNY58_04250) 924664..926148 - 1485 WP_099091321.1 cardiolipin synthase -
MNY58_RS04255 (MNY58_04255) 926292..926585 + 294 WP_099091320.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNY58_RS04260 (MNY58_04260) 926600..926806 + 207 WP_099091319.1 heavy metal-associated domain-containing protein Toxin
MNY58_RS04265 (MNY58_04265) 927018..927158 + 141 WP_099091318.1 Lmo0850 family protein -
MNY58_RS04270 (MNY58_04270) 927485..928669 - 1185 WP_099091317.1 FtsW/RodA/SpoVE family cell cycle protein -
MNY58_RS04275 (MNY58_04275) 928919..929989 + 1071 WP_099091316.1 D-alanine--D-alanine ligase -
MNY58_RS04280 (MNY58_04280) 930002..931357 + 1356 WP_099091315.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7879.02 Da        Isoelectric Point: 4.4944

>T237811 WP_099091319.1 NZ_CP093217:926600-926806 [Staphylococcus edaphicus]
MQSKVIYIAGLNNEIQKSQIEQKLLQLHGVHKVLIEKDEGEIFVDFETPASLNNLEKEVYDLGYQILY

Download         Length: 207 bp

>T237811 NZ_LR882967:2652062-2652469 [Planktothrix pseudagardhii]
ATGTTTCTGATTGATACTTCTGTTTGGATAAGTGTTTTCCGTGATCGCACAGGTGCAGTACGTCAATCCCTCGAAGCAAT
AATTAACAATAAAAGTATTTTTTTGAGTCGATTTACTCAGATGGAACTTTTGCAAGGTTGCCGAGACGATCGCGAGTGGA
CGCTATTAGAAACTTATCTTCAAGATCAAGACTATATCGAGGCTACTGCCGATACTTGGGTTGCTGCTGCCCGAATTTAT
TACGATTTACAACGACAGGGGTTAACGGTTAGAAGTAGTATCGACTGCTGCATTGCCCAATTAGCGATCAAACATCAACT
CACTCTAGTTCATAACGATCGCGATTTTGAAACAATTCAGAGGGTGCGATCGCTCAATTGTTTGCGCTTTCGACCTGAAA
ATAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11183.90 Da        Isoelectric Point: 6.0845

>AT237811 WP_099091320.1 NZ_CP093217:926292-926585 [Staphylococcus edaphicus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGQE
VEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT237811 NZ_LR882967:2652571-2652804 [Planktothrix pseudagardhii]
ATGAATTTAACGACTGGCTTGCTAAACCGTATTACTCAAACTCCAGGTCAATGTGGTGGTCGTCCTTGTATTCGAGGGAT
GCGAATTCGAGTCACTGATATTTTAGAAATGTTGGCGGAAAATGTTAGCATTACTGAAATTTTAGAAGACTTCCCGGATT
TGGAATTAGCAGATATTCAAGCTTGTTTGCTGTTTGCCGCACGACGCACTGATTTTCCTAGACTAACAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References