Detailed information of TA system TA237809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2227299..2227769
• Replicon: chromosome
• Accession: NZ_CP093212
• Organism: Staphylococcus epidermidis strain TSM-51

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU32_RS10835
• Protein ID: WP_001829569.1
• Coordinates: 2227581..2227769 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU32_RS10830
• Protein ID: WP_002438963.1
• Coordinates: 2227299..2227556 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU32_RS10790 (MNU32_10790)	2222663..2223379	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
MNU32_RS10795 (MNU32_10795)	2223540..2223962	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
MNU32_RS10800 (MNU32_10800)	2224146..2224301	-	156	WP_001829648.1	hypothetical protein	-
MNU32_RS10805 (MNU32_10805)	2224313..2224500	-	188	Protein_2099	hypothetical protein	-
MNU32_RS10810 (MNU32_10810)	2224887..2225387	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU32_RS10815 (MNU32_10815)	2225658..2226245	-	588	WP_001829615.1	histidine phosphatase family protein	-
MNU32_RS10820 (MNU32_10820)	2226459..2226695	+	237	WP_002457224.1	hypothetical protein	-
MNU32_RS10825 (MNU32_10825)	2226687..2226890	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU32_RS10830 (MNU32_10830)	2227299..2227556	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU32_RS10835 (MNU32_10835)	2227581..2227769	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU32_RS10840 (MNU32_10840)	2227959..2228513	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
MNU32_RS10845 (MNU32_10845)	2228573..2228806	-	234	WP_001829664.1	hypothetical protein	-
MNU32_RS10850 (MNU32_10850)	2229090..2229836	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU32_RS10855 (MNU32_10855)	2229935..2230219	+	285	WP_001829635.1	hypothetical protein	-
MNU32_RS10860 (MNU32_10860)	2230243..2230467	+	225	WP_001829613.1	hypothetical protein	-
MNU32_RS10865 (MNU32_10865)	2231088..2231288	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2224146..2224301	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-62)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237809 WP_001829569.1 NZ_CP093212:2227581-2227769 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237809 NZ_LR882967:2162328-2162522 [Planktothrix pseudagardhii]
ATGAAAGTTCGTGAGGTACTCAAGAGATTAGAAGCGGATGGATGGTATGAAGCAAGAATGCGAGGAAGTCATCGAGTCCT
AAAACATCCTGAAAAATCCGGTATCGTTGTTGTACTGGGTAATTTTTCTGATGAAGTTGCTATTGGAACTCTCAAAAGTA
TCTGGAAACAAGCACAATTAGAGGATCAATCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237809 WP_002438963.1 NZ_CP093212:2227299-2227556 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237809 NZ_LR882967:2162519-2162734 [Planktothrix pseudagardhii]
ATGAAAGAATATGTTGCAATTTTTGAATGGGCTGGGAGTAATTATTCTGCTTACGTTCCTGATTTACCCGGTTGTATTTC
TACAGGAAAAACCTTAGAAGAAACCGCAAATAATATTAAAGAAGCGATTGAATTGTATATTGACACTCTGCGAGAAGATG
GTCAAGCTATTCCCGAACCTTCTCTAACCGTTAAGACAATTTCTGTTGCTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3