237808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2087600..2088403 Replicon chromosome
Accession NZ_CP093212
Organism Staphylococcus epidermidis strain TSM-51

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MNU32_RS10115 Protein ID WP_002484735.1
Coordinates 2087942..2088403 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MNU32_RS10110 Protein ID WP_002484747.1
Coordinates 2087600..2087929 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU32_RS10080 (MNU32_10080) 2082612..2083535 - 924 WP_059223500.1 recombinase RecT -
MNU32_RS10085 (MNU32_10085) 2083537..2085489 - 1953 WP_194086741.1 AAA family ATPase -
MNU32_RS10090 (MNU32_10090) 2085822..2086088 + 267 WP_002456364.1 hypothetical protein -
MNU32_RS10095 (MNU32_10095) 2086215..2086424 - 210 WP_001830281.1 hypothetical protein -
MNU32_RS10100 (MNU32_10100) 2086437..2087153 - 717 WP_002468739.1 phage repressor protein -
MNU32_RS10105 (MNU32_10105) 2087167..2087406 - 240 WP_194086740.1 helix-turn-helix transcriptional regulator -
MNU32_RS10110 (MNU32_10110) 2087600..2087929 + 330 WP_002484747.1 helix-turn-helix transcriptional regulator Antitoxin
MNU32_RS10115 (MNU32_10115) 2087942..2088403 + 462 WP_002484735.1 ImmA/IrrE family metallo-endopeptidase Toxin
MNU32_RS10120 (MNU32_10120) 2088572..2088739 + 168 WP_002497581.1 hypothetical protein -
MNU32_RS10125 (MNU32_10125) 2088761..2089900 + 1140 WP_103422872.1 CapA family protein -
MNU32_RS10130 (MNU32_10130) 2090085..2090636 + 552 WP_103422871.1 Ltp family lipoprotein -
MNU32_RS10135 (MNU32_10135) 2090699..2091748 + 1050 WP_001830299.1 site-specific integrase -
MNU32_RS10150 (MNU32_10150) 2092149..2092724 - 576 WP_001829272.1 competence protein ComK -
MNU32_RS10155 (MNU32_10155) 2092939..2093157 + 219 WP_001829292.1 IDEAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2047204..2091748 44544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(33-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17881.48 Da        Isoelectric Point: 5.0503

>T237808 WP_002484735.1 NZ_CP093212:2087942-2088403 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYGLTTRCGDYVIAFEPLRVFEYKEI

Download         Length: 462 bp

>T237808 NZ_LR882967:1664882-1665403 [Planktothrix pseudagardhii]
GTGGGATTAGATCGAGATCGAGACAAACTCAGCCCTCCTGAAAAACTAAATCCGTCACATCAAATTGATAACTTTGATTC
GGGTAACAGTCAGTTAGATGACTGGCTCAAGCGTCGTGCTTGGAAAAATGAGTTAGAAGGGGCTTCCCGCACTTATGTTC
TTTGTGTGGGTGAAGTCGTCGTTGCGTACTACTGTCTTGCCAACGGCGCAGTAGCTCGAAATATTGCTACAGGAGGAGTT
CGGCGTAATATGCCCGATCCAATTCCGGTTATGATTATCGGAAGATTGGCCGTTGATCGCCAGTGGCAAAACCAAGGTAT
CGGGCGTGCTATGCTACGAGATGCGATTCTTCGCACGCTACAAGCGGCTGAAATTGCGGGAATACGAGCAATTCTTGTCC
ATGCTATCTCGGAAGAGGCAAAGCTCTTTTATCAGAAGTATGGGTTTGCTGCCTTAGAGAGCGATCCGATGATACTGATG
GTAAAAGTTAGTGATGCCATTATTTCACTTGGGTTAGGGTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12708.21 Da        Isoelectric Point: 4.8033

>AT237808 WP_002484747.1 NZ_CP093212:2087600-2087929 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPQH
RAAHLDGDLTDEEWQEILDYAEYIRSKRK

Download         Length: 330 bp

>AT237808 NZ_LR882967:1664559-1664891 [Planktothrix pseudagardhii]
TTGCAATTGAGTTTAGCTCTCACAGAGGTAGCAGCTATGTATGGGTCAGAAGCTCAACAGTCAGTCAGCCAGACCCGCGA
GGTGACGATCAATATCCGAGCCAAGCAGAGTCAACGGGATTTTATCGATCAAGCTGCTAAAATACAAGGCAAAAGCCGAT
CAGAGTTCATGCTTCAAACAGCTTACCAAAAAGCCCAAGATGTGATTTTAAGTCGCTGTTTTTTTGAGTTAGATGAGGGT
AAATTTCAGAAATTCGTGGATCTGTTAGATGCACCACCTCTGCAAAATGAGAAATTAAAAGCATTGTTAACCACTAAATC
GCCGTGGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References