237805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 870257..870786 Replicon chromosome
Accession NZ_CP093212
Organism Staphylococcus epidermidis strain TSM-51

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU32_RS04065 Protein ID WP_001829891.1
Coordinates 870424..870786 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU32_RS04060 Protein ID WP_001829931.1
Coordinates 870257..870427 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU32_RS04035 (MNU32_04035) 866082..866561 + 480 WP_001829909.1 PH domain-containing protein -
MNU32_RS04040 (MNU32_04040) 866554..868059 + 1506 WP_001829976.1 PH domain-containing protein -
MNU32_RS04045 (MNU32_04045) 868046..868555 + 510 WP_001829888.1 PH domain-containing protein -
MNU32_RS04050 (MNU32_04050) 868603..868956 + 354 WP_001829915.1 holo-ACP synthase -
MNU32_RS04055 (MNU32_04055) 869022..870170 + 1149 WP_002468951.1 alanine racemase -
MNU32_RS04060 (MNU32_04060) 870257..870427 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU32_RS04065 (MNU32_04065) 870424..870786 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU32_RS04070 (MNU32_04070) 871132..872133 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU32_RS04075 (MNU32_04075) 872233..872559 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU32_RS04080 (MNU32_04080) 872561..873040 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU32_RS04085 (MNU32_04085) 873015..873785 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237805 WP_001829891.1 NZ_CP093212:870424-870786 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237805 NZ_LR882963:c4511711-4511430 [Planktothrix agardhii]
GTGCTCATAGTCGTACAAGTAACAGCAATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGA
TCGGGTAGTTGAAGATGCTGACTACACCATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATT
TTAATGGTTTACTGGAAACGGTTCATTTATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATAT
AGGCAGGGGAAAGCTCTTGAACATCAGTTGATAGATGAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237805 WP_001829931.1 NZ_CP093212:870257-870427 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237805 NZ_LR882963:c4511437-4511288 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References