237804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 859074..859583 Replicon chromosome
Accession NZ_CP093212
Organism Staphylococcus epidermidis strain TSM-51

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU32_RS04005 Protein ID WP_001829980.1
Coordinates 859374..859583 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU32_RS04000 Protein ID WP_001829893.1
Coordinates 859074..859367 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU32_RS03975 (MNU32_03975) 854082..854870 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MNU32_RS03980 (MNU32_03980) 854876..855514 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU32_RS03985 (MNU32_03985) 855603..856475 + 873 WP_002458703.1 membrane protein insertase YidC -
MNU32_RS03990 (MNU32_03990) 856581..857234 - 654 WP_001829983.1 HD domain-containing protein -
MNU32_RS03995 (MNU32_03995) 857416..858900 - 1485 WP_002457116.1 cardiolipin synthase -
MNU32_RS04000 (MNU32_04000) 859074..859367 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU32_RS04005 (MNU32_04005) 859374..859583 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU32_RS04010 (MNU32_04010) 859726..859863 + 138 WP_001829949.1 Lmo0850 family protein -
MNU32_RS04015 (MNU32_04015) 859963..861174 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU32_RS04020 (MNU32_04020) 861565..862638 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU32_RS04025 (MNU32_04025) 862650..864005 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237804 WP_001829980.1 NZ_CP093212:859374-859583 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237804 NZ_LR882963:c4511437-4511288 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237804 WP_001829893.1 NZ_CP093212:859074-859367 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237804 NZ_LR882963:c4511711-4511430 [Planktothrix agardhii]
GTGCTCATAGTCGTACAAGTAACAGCAATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGA
TCGGGTAGTTGAAGATGCTGACTACACCATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATT
TTAATGGTTTACTGGAAACGGTTCATTTATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATAT
AGGCAGGGGAAAGCTCTTGAACATCAGTTGATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References