Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1657638..1658147 Replicon chromosome
Accession NZ_CP093210
Organism Staphylococcus epidermidis strain TSM-50

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU50_RS07770 Protein ID WP_001829980.1
Coordinates 1657638..1657847 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU50_RS07775 Protein ID WP_001829893.1
Coordinates 1657854..1658147 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU50_RS07750 (MNU50_07735) 1653217..1654572 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MNU50_RS07755 (MNU50_07740) 1654584..1655657 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MNU50_RS07760 (MNU50_07745) 1656048..1657259 + 1212 WP_002457115.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU50_RS07765 (MNU50_07750) 1657358..1657495 - 138 WP_001829949.1 Lmo0850 family protein -
MNU50_RS07770 (MNU50_07755) 1657638..1657847 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU50_RS07775 (MNU50_07760) 1657854..1658147 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU50_RS07780 (MNU50_07765) 1658321..1659805 + 1485 WP_002457116.1 cardiolipin synthase -
MNU50_RS07785 (MNU50_07770) 1659987..1660640 + 654 WP_001829983.1 HD domain-containing protein -
MNU50_RS07790 (MNU50_07775) 1660746..1661618 - 873 WP_002470121.1 membrane protein insertase YidC -
MNU50_RS07795 (MNU50_07780) 1661707..1662345 - 639 WP_002505076.1 thiamine phosphate synthase -
MNU50_RS07800 (MNU50_07785) 1662351..1663139 - 789 WP_002469583.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237803 WP_001829980.1 NZ_CP093210:c1657847-1657638 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237803 NZ_LR882963:c3265655-3265485 [Planktothrix agardhii]
ATTAAACGACTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATTTAAACATCCTGTAAAATC
TGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTATTATTAAACAAGCTCAAA
TTCATCTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237803 WP_001829893.1 NZ_CP093210:c1658147-1657854 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237803 NZ_LR882963:c3265464-3265255 [Planktothrix agardhii]
ATGAAACGTTATGCAATTGTTATTGAAAAAACGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACAGGTTACACCCTAGAAGAAATTGAAACCGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GCTTACCGATTCCTGAACCTATGGCTATATCCGAATATGTTGAAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References