Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1646433..1646962 Replicon chromosome
Accession NZ_CP093210
Organism Staphylococcus epidermidis strain TSM-50

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU50_RS07710 Protein ID WP_001829891.1
Coordinates 1646433..1646795 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU50_RS07715 Protein ID WP_001829931.1
Coordinates 1646792..1646962 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU50_RS07690 (MNU50_07675) 1643441..1644211 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
MNU50_RS07695 (MNU50_07680) 1644186..1644659 - 474 WP_002469585.1 anti-sigma B factor RsbW -
MNU50_RS07700 (MNU50_07685) 1644661..1644987 - 327 WP_001829952.1 anti-sigma factor antagonist -
MNU50_RS07705 (MNU50_07690) 1645087..1646088 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU50_RS07710 (MNU50_07695) 1646433..1646795 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU50_RS07715 (MNU50_07700) 1646792..1646962 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU50_RS07720 (MNU50_07705) 1647049..1648197 - 1149 WP_002457107.1 alanine racemase -
MNU50_RS07725 (MNU50_07710) 1648264..1648617 - 354 WP_002457108.1 holo-ACP synthase -
MNU50_RS07730 (MNU50_07715) 1648665..1649174 - 510 WP_002457109.1 PH domain-containing protein -
MNU50_RS07735 (MNU50_07720) 1649161..1650666 - 1506 WP_002457110.1 PH domain-containing protein -
MNU50_RS07740 (MNU50_07725) 1650659..1651138 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237802 WP_001829891.1 NZ_CP093210:c1646795-1646433 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237802 NZ_LR882963:c2768003-2767731 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237802 WP_001829931.1 NZ_CP093210:c1646962-1646792 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237802 NZ_LR882963:c2767750-2767526 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGAAACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References