Detailed information of TA system TA237800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 538395..538865
• Replicon: chromosome
• Accession: NZ_CP093210
• Organism: Staphylococcus epidermidis strain TSM-50

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU50_RS02420
• Protein ID: WP_001829569.1
• Coordinates: 538395..538583 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU50_RS02425
• Protein ID: WP_002438963.1
• Coordinates: 538608..538865 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU50_RS02390 (MNU50_02390)	534876..535076	+	201	WP_001829681.1	cold-shock protein	-
MNU50_RS02395 (MNU50_02395)	535697..535921	-	225	WP_001829613.1	hypothetical protein	-
MNU50_RS02400 (MNU50_02400)	535945..536229	-	285	WP_001829635.1	hypothetical protein	-
MNU50_RS02405 (MNU50_02405)	536328..537074	-	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU50_RS02410 (MNU50_02410)	537358..537591	+	234	WP_001829664.1	hypothetical protein	-
MNU50_RS02415 (MNU50_02415)	537651..538205	-	555	WP_002469327.1	lipoprotein N-acylation protein LnsA	-
MNU50_RS02420 (MNU50_02420)	538395..538583	-	189	WP_001829569.1	hypothetical protein	Toxin
MNU50_RS02425 (MNU50_02425)	538608..538865	-	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU50_RS02430 (MNU50_02430)	539274..539477	+	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU50_RS02435 (MNU50_02435)	539469..539705	-	237	WP_002457224.1	hypothetical protein	-
MNU50_RS02440 (MNU50_02440)	539919..540506	+	588	WP_254105135.1	histidine phosphatase family protein	-
MNU50_RS02445 (MNU50_02445)	540777..541277	-	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU50_RS02450 (MNU50_02450)	541895..543073	+	1179	WP_104832443.1	IS110 family transposase	-
MNU50_RS02455 (MNU50_02455)	543224..543411	+	188	Protein_486	hypothetical protein	-
MNU50_RS02460 (MNU50_02460)	543441..543578	+	138	WP_162161215.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-45)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237800 WP_001829569.1 NZ_CP093210:c538583-538395 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237800 NZ_LR882952:3639064-3639462 [Planktothrix agardhii]
GTGAAATTATTGTTGGATACCCAATGCTGGTTGTGGTGGTTTGCCCAACCTGAGCGATTAAATCAAGAAGTGATCGCACA
GATTGCCGATGAAAGTAATGAATTATGGTTTTCTGTTGCTAGTGTTTGGGAAATTGGGATCAAAGTTGCGATCAGAAAAT
TACCATTGCCAGAGCCAATAGATACCTACATTTCTAGTCGTATGGTGCAGTTAGATATGCGATATTTAGAAATCAAAGCA
CCTCATGCACTGCGATCATCTGCATTGCCATTACATCATCGAGATCCCTTTGATCGTATGTTGATTGCTCAGGCTCAAAT
TGAGAATATGACGCTGGTGAGTGCTGATTCAATATTCAAGCAATACAGCGATATTTCTGTTCTTTGGGCTGCTAATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237800 WP_002438963.1 NZ_CP093210:c538865-538608 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237800 NZ_LR882952:3638806-3639051 [Planktothrix agardhii]
ATGGCTAAACTTCAGATTGAAAACTTACCCAACGACTTCAAAAAAAATCTCTCTGAGTTATTGTCTCGTGTAGAACTTGG
AGAAGAAATTATTATTTCCAATCAAGGGGTGGCGATCGCGAAGTTAATTCCGTTTCGTCCTTCATCCAATCGACGGGCGA
GTTTAGGGCAAGATCAAGGTAAATTTATCATACCAGACGACTTTAATGAACCGTTACCCCAAGAAATTTTGGCAGCATTT
GAATGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3