Detailed information of TA system TA237799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2006208..2006678
• Replicon: chromosome
• Accession: NZ_CP093208
• Organism: Staphylococcus epidermidis strain TSM-47

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU33_RS09685
• Protein ID: WP_001829569.1
• Coordinates: 2006490..2006678 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU33_RS09680
• Protein ID: WP_002438963.1
• Coordinates: 2006208..2006465 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU33_RS09640 (MNU33_09630)	2001572..2002288	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
MNU33_RS09645 (MNU33_09635)	2002449..2002871	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
MNU33_RS09650 (MNU33_09640)	2003055..2003192	-	138	WP_162161215.1	hypothetical protein	-
MNU33_RS09655 (MNU33_09645)	2003222..2003409	-	188	Protein_1869	hypothetical protein	-
MNU33_RS09660 (MNU33_09650)	2003796..2004296	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU33_RS09665 (MNU33_09655)	2004567..2005154	-	588	WP_001829615.1	histidine phosphatase family protein	-
MNU33_RS09670 (MNU33_09660)	2005368..2005604	+	237	WP_002457224.1	hypothetical protein	-
MNU33_RS09675 (MNU33_09665)	2005596..2005799	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU33_RS09680 (MNU33_09670)	2006208..2006465	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU33_RS09685 (MNU33_09675)	2006490..2006678	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU33_RS09690 (MNU33_09680)	2006868..2007422	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
MNU33_RS09695 (MNU33_09685)	2007482..2007715	-	234	WP_001829664.1	hypothetical protein	-
MNU33_RS09700 (MNU33_09690)	2007999..2008745	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU33_RS09705 (MNU33_09695)	2008844..2009128	+	285	WP_001829635.1	hypothetical protein	-
MNU33_RS09710 (MNU33_09700)	2009152..2009376	+	225	WP_001829613.1	hypothetical protein	-
MNU33_RS09715 (MNU33_09705)	2009997..2010197	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2003055..2003210	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Antitoxin

• Toxin YoeB (8-37)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237799 WP_001829569.1 NZ_CP093208:2006490-2006678 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237799 NZ_LR882952:c3602814-3602560 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237799 WP_002438963.1 NZ_CP093208:2006208-2006465 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237799 NZ_LR882952:c3602567-3602418 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3