Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
Location | 1820982..1821784 | Replicon | chromosome |
Accession | NZ_CP093208 | ||
Organism | Staphylococcus epidermidis strain TSM-47 |
Toxin (Protein)
Gene name | - | Uniprot ID | - |
Locus tag | MNU33_RS08580 | Protein ID | WP_002439258.1 |
Coordinates | 1821323..1821784 (+) | Length | 154 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | - |
Locus tag | MNU33_RS08575 | Protein ID | WP_002439260.1 |
Coordinates | 1820982..1821311 (+) | Length | 110 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU33_RS08530 (MNU33_08525) | 1816730..1817260 | + | 531 | WP_002439277.1 | N-acetyltransferase | - |
MNU33_RS08535 (MNU33_08530) | 1817496..1817693 | + | 198 | WP_002456096.1 | hypothetical protein | - |
MNU33_RS08540 (MNU33_08535) | 1818086..1818319 | - | 234 | Protein_1648 | ATP-binding protein | - |
MNU33_RS08545 (MNU33_08540) | 1818694..1819017 | + | 324 | WP_002456098.1 | hypothetical protein | - |
MNU33_RS08550 (MNU33_08545) | 1819148..1819360 | - | 213 | Protein_1650 | DUF771 domain-containing protein | - |
MNU33_RS08555 (MNU33_08550) | 1819364..1820128 | - | 765 | WP_002439267.1 | phage regulatory protein/antirepressor Ant | - |
MNU33_RS08560 (MNU33_08555) | 1820178..1820384 | + | 207 | WP_002439266.1 | hypothetical protein | - |
MNU33_RS08565 (MNU33_08560) | 1820373..1820537 | - | 165 | WP_002439265.1 | hypothetical protein | - |
MNU33_RS08570 (MNU33_08565) | 1820534..1820788 | - | 255 | WP_002439263.1 | helix-turn-helix transcriptional regulator | - |
MNU33_RS08575 (MNU33_08570) | 1820982..1821311 | + | 330 | WP_002439260.1 | helix-turn-helix transcriptional regulator | Antitoxin |
MNU33_RS08580 (MNU33_08575) | 1821323..1821784 | + | 462 | WP_002439258.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
MNU33_RS08585 (MNU33_08580) | 1821800..1822318 | + | 519 | WP_002439256.1 | hypothetical protein | - |
MNU33_RS08590 (MNU33_08585) | 1822320..1822763 | + | 444 | WP_002439254.1 | hypothetical protein | - |
MNU33_RS08595 (MNU33_08590) | 1822836..1823030 | + | 195 | WP_002439253.1 | hypothetical protein | - |
MNU33_RS08600 (MNU33_08595) | 1823099..1823614 | + | 516 | WP_002439252.1 | hypothetical protein | - |
MNU33_RS08605 (MNU33_08600) | 1823616..1823951 | + | 336 | WP_002439251.1 | hypothetical protein | - |
MNU33_RS08610 (MNU33_08605) | 1824007..1824405 | + | 399 | Protein_1662 | phage integrase SAM-like domain-containing protein | - |
MNU33_RS08615 (MNU33_08610) | 1824511..1824981 | + | 471 | Protein_1663 | site-specific integrase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1815185..1867595 | 52410 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18370.06 Da Isoelectric Point: 6.8511
>T237798 WP_002439258.1 NZ_CP093208:1821323-1821784 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYENALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYENALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI
Download Length: 462 bp
>T237798 NZ_LR882952:c3602567-3602418 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12735.32 Da Isoelectric Point: 5.7917
>AT237798 WP_002439260.1 NZ_CP093208:1820982-1821311 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK
Download Length: 330 bp
>AT237798 NZ_LR882952:c3602814-3602560 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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