Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1820982..1821784 Replicon chromosome
Accession NZ_CP093208
Organism Staphylococcus epidermidis strain TSM-47

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MNU33_RS08580 Protein ID WP_002439258.1
Coordinates 1821323..1821784 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MNU33_RS08575 Protein ID WP_002439260.1
Coordinates 1820982..1821311 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU33_RS08530 (MNU33_08525) 1816730..1817260 + 531 WP_002439277.1 N-acetyltransferase -
MNU33_RS08535 (MNU33_08530) 1817496..1817693 + 198 WP_002456096.1 hypothetical protein -
MNU33_RS08540 (MNU33_08535) 1818086..1818319 - 234 Protein_1648 ATP-binding protein -
MNU33_RS08545 (MNU33_08540) 1818694..1819017 + 324 WP_002456098.1 hypothetical protein -
MNU33_RS08550 (MNU33_08545) 1819148..1819360 - 213 Protein_1650 DUF771 domain-containing protein -
MNU33_RS08555 (MNU33_08550) 1819364..1820128 - 765 WP_002439267.1 phage regulatory protein/antirepressor Ant -
MNU33_RS08560 (MNU33_08555) 1820178..1820384 + 207 WP_002439266.1 hypothetical protein -
MNU33_RS08565 (MNU33_08560) 1820373..1820537 - 165 WP_002439265.1 hypothetical protein -
MNU33_RS08570 (MNU33_08565) 1820534..1820788 - 255 WP_002439263.1 helix-turn-helix transcriptional regulator -
MNU33_RS08575 (MNU33_08570) 1820982..1821311 + 330 WP_002439260.1 helix-turn-helix transcriptional regulator Antitoxin
MNU33_RS08580 (MNU33_08575) 1821323..1821784 + 462 WP_002439258.1 ImmA/IrrE family metallo-endopeptidase Toxin
MNU33_RS08585 (MNU33_08580) 1821800..1822318 + 519 WP_002439256.1 hypothetical protein -
MNU33_RS08590 (MNU33_08585) 1822320..1822763 + 444 WP_002439254.1 hypothetical protein -
MNU33_RS08595 (MNU33_08590) 1822836..1823030 + 195 WP_002439253.1 hypothetical protein -
MNU33_RS08600 (MNU33_08595) 1823099..1823614 + 516 WP_002439252.1 hypothetical protein -
MNU33_RS08605 (MNU33_08600) 1823616..1823951 + 336 WP_002439251.1 hypothetical protein -
MNU33_RS08610 (MNU33_08605) 1824007..1824405 + 399 Protein_1662 phage integrase SAM-like domain-containing protein -
MNU33_RS08615 (MNU33_08610) 1824511..1824981 + 471 Protein_1663 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1815185..1867595 52410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(25-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18370.06 Da        Isoelectric Point: 6.8511

>T237798 WP_002439258.1 NZ_CP093208:1821323-1821784 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYENALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T237798 NZ_LR882952:c3602567-3602418 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT237798 WP_002439260.1 NZ_CP093208:1820982-1821311 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT237798 NZ_LR882952:c3602814-3602560 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References