Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 846708..847237 Replicon chromosome
Accession NZ_CP093208
Organism Staphylococcus epidermidis strain TSM-47

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU33_RS03965 Protein ID WP_001829891.1
Coordinates 846875..847237 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU33_RS03960 Protein ID WP_001829931.1
Coordinates 846708..846878 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU33_RS03935 (MNU33_03930) 842533..843012 + 480 WP_001829909.1 PH domain-containing protein -
MNU33_RS03940 (MNU33_03935) 843005..844510 + 1506 WP_001829976.1 PH domain-containing protein -
MNU33_RS03945 (MNU33_03940) 844497..845006 + 510 WP_001829888.1 PH domain-containing protein -
MNU33_RS03950 (MNU33_03945) 845054..845407 + 354 WP_001829915.1 holo-ACP synthase -
MNU33_RS03955 (MNU33_03950) 845473..846621 + 1149 WP_001829972.1 alanine racemase -
MNU33_RS03960 (MNU33_03955) 846708..846878 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU33_RS03965 (MNU33_03960) 846875..847237 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU33_RS03970 (MNU33_03965) 847583..848584 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU33_RS03975 (MNU33_03970) 848684..849010 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU33_RS03980 (MNU33_03975) 849012..849491 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU33_RS03985 (MNU33_03980) 849466..850236 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237796 WP_001829891.1 NZ_CP093208:846875-847237 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237796 NZ_LR882952:c1887174-1886902 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237796 WP_001829931.1 NZ_CP093208:846708-846878 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237796 NZ_LR882952:c1886921-1886697 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References