Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 846708..847237 | Replicon | chromosome |
Accession | NZ_CP093208 | ||
Organism | Staphylococcus epidermidis strain TSM-47 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | Q5HME7 |
Locus tag | MNU33_RS03965 | Protein ID | WP_001829891.1 |
Coordinates | 846875..847237 (+) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | Q5HME6 |
Locus tag | MNU33_RS03960 | Protein ID | WP_001829931.1 |
Coordinates | 846708..846878 (+) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU33_RS03935 (MNU33_03930) | 842533..843012 | + | 480 | WP_001829909.1 | PH domain-containing protein | - |
MNU33_RS03940 (MNU33_03935) | 843005..844510 | + | 1506 | WP_001829976.1 | PH domain-containing protein | - |
MNU33_RS03945 (MNU33_03940) | 844497..845006 | + | 510 | WP_001829888.1 | PH domain-containing protein | - |
MNU33_RS03950 (MNU33_03945) | 845054..845407 | + | 354 | WP_001829915.1 | holo-ACP synthase | - |
MNU33_RS03955 (MNU33_03950) | 845473..846621 | + | 1149 | WP_001829972.1 | alanine racemase | - |
MNU33_RS03960 (MNU33_03955) | 846708..846878 | + | 171 | WP_001829931.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
MNU33_RS03965 (MNU33_03960) | 846875..847237 | + | 363 | WP_001829891.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MNU33_RS03970 (MNU33_03965) | 847583..848584 | + | 1002 | WP_001829902.1 | PP2C family protein-serine/threonine phosphatase | - |
MNU33_RS03975 (MNU33_03970) | 848684..849010 | + | 327 | WP_001829952.1 | anti-sigma factor antagonist | - |
MNU33_RS03980 (MNU33_03975) | 849012..849491 | + | 480 | WP_001829903.1 | anti-sigma B factor RsbW | - |
MNU33_RS03985 (MNU33_03980) | 849466..850236 | + | 771 | WP_002440602.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13497.65 Da Isoelectric Point: 9.9522
>T237796 WP_001829891.1 NZ_CP093208:846875-847237 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS
Download Length: 363 bp
>T237796 NZ_LR882952:c1887174-1886902 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6289.92 Da Isoelectric Point: 4.1920
>AT237796 WP_001829931.1 NZ_CP093208:846708-846878 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE
Download Length: 171 bp
>AT237796 NZ_LR882952:c1886921-1886697 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HWR0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0N1EF65 |