Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 835525..836034 Replicon chromosome
Accession NZ_CP093208
Organism Staphylococcus epidermidis strain TSM-47

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU33_RS03905 Protein ID WP_001829980.1
Coordinates 835825..836034 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU33_RS03900 Protein ID WP_001829893.1
Coordinates 835525..835818 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU33_RS03875 (MNU33_03870) 830533..831321 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MNU33_RS03880 (MNU33_03875) 831327..831965 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU33_RS03885 (MNU33_03880) 832054..832926 + 873 WP_001832740.1 membrane protein insertase YidC -
MNU33_RS03890 (MNU33_03885) 833032..833685 - 654 WP_001829983.1 HD domain-containing protein -
MNU33_RS03895 (MNU33_03890) 833867..835351 - 1485 WP_001829964.1 cardiolipin synthase -
MNU33_RS03900 (MNU33_03895) 835525..835818 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU33_RS03905 (MNU33_03900) 835825..836034 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU33_RS03910 (MNU33_03905) 836177..836314 + 138 WP_001829949.1 Lmo0850 family protein -
MNU33_RS03915 (MNU33_03910) 836414..837625 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU33_RS03920 (MNU33_03915) 838016..839089 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU33_RS03925 (MNU33_03920) 839101..840456 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237795 WP_001829980.1 NZ_CP093208:835825-836034 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237795 NZ_LR882952:1504859-1505428 [Planktothrix agardhii]
GTGGCTAATTTTTCCGTTGTCTACGATGCTTGTGTTTTATATCCAGCACCGCTTCGTGATTTTTTAATGGAACTTGCCAT
CACTGACTTATTTAAGGCACTTTGGACAGATGCTATTCACGATGAATGGATCAGAAATGTTCTCAAAAATCGTCCTGATC
TTACACTTGAACAGCTTACCAGGACTAAAACTCTGATGAATTCTCATGTTAGAGATTGCCTGGTTACAGGATACGAAGAC
CTAATATTAGGATTACAACTTCCTGATCCAGATGATCGTCATGTTCTTGCTGCTGCCATTCGCTGTAATGCTGATGTAAT
TGTCACTTTTAATCTTGATGATTTTCCCAGTCAAGCACTTCAACAATATGGTGTTGAAGCGCAGCACCCGGATGAGTTTA
TTCTACACTTACTCGACTTGAACCCAGCAATGGTCTGTAGAGCAGCCGAAATACAACGAATCAGACTTAAAAATCCACCT
AAAACACCTGATGAATATCTGGACACGCTTCTAAAACAAGGACTTCCGCAGTCCGTGAGTACGTTAAGGGAGTTGTGTTA
TGGAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237795 WP_001829893.1 NZ_CP093208:835525-835818 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237795 NZ_LR882952:1504374-1504859 [Planktothrix agardhii]
ATGACACTTACAGAGGCTCCAAACTTGCGGTCTGTTCTACCTACGGAAGAAGAAGCTACGATTGCACAAGCCAGTAGCTC
GTCTTTGGCACGGTACATCAAGAACCAAGACGGATGCACCCGTACCATCAAGCTTGTGCAAGATGACAGCCAAGATGAAG
TTGTTGTCATACCTGCTGAAGCTTTTCGTCTACTGCTTGAGATGTTGGCACAGATGGCGAAGGGAAATGCTGTAACGCTG
ATTCCAATTCACGCAGAACTTACCACCCAAGAAGCTGCTGACATTTTGAATGTTTCCCGTCCCTATTTGGTGCAACTGCT
GGAGTCTGGAGAAATCCCTTTTCGTAAAGTGGGTACGCGCCGAAGGGTGCGTTACCAAGATTTAATGGACTACAAAAATC
GAGTTGATGCAGCACGACGGAAAACTCTTGATGAGCTTACTACTCAAGCTCAAGAACTGAATATGGGATACGAAGGAGTC
ATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References