Detailed information of TA system TA237794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2286354..2287156
• Replicon: chromosome
• Accession: NZ_CP093205
• Organism: Staphylococcus epidermidis strain TSM-36

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU43_RS10885
• Protein ID: WP_021298894.1
• Coordinates: 2286695..2287156 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU43_RS10880
• Protein ID: WP_002493408.1
• Coordinates: 2286354..2286683 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU43_RS10835 (MNU43_10820)	2281659..2282387	-	729	WP_002485813.1	DnaD domain protein	-
MNU43_RS10840 (MNU43_10825)	2282387..2283052	-	666	WP_254106818.1	putative HNHc nuclease	-
MNU43_RS10845 (MNU43_10830)	2283066..2283488	-	423	WP_254106819.1	single-stranded DNA-binding protein	-
MNU43_RS10850 (MNU43_10835)	2283488..2284159	-	672	WP_002468900.1	ERF family protein	-
MNU43_RS10855 (MNU43_10840)	2284152..2284379	-	228	WP_002468899.1	DUF2483 family protein	-
MNU43_RS10860 (MNU43_10845)	2284351..2284626	-	276	WP_254106820.1	chordopoxvirus fusion protein	-
MNU43_RS10865 (MNU43_10850)	2284952..2285119	-	168	WP_016050554.1	hypothetical protein	-
MNU43_RS10870 (MNU43_10855)	2285133..2285906	-	774	WP_021298911.1	phage antirepressor	-
MNU43_RS10875 (MNU43_10860)	2285921..2286160	-	240	WP_021298897.1	helix-turn-helix transcriptional regulator	-
MNU43_RS10880 (MNU43_10865)	2286354..2286683	+	330	WP_002493408.1	helix-turn-helix transcriptional regulator	Antitoxin
MNU43_RS10885 (MNU43_10870)	2286695..2287156	+	462	WP_021298894.1	hypothetical protein	Toxin
MNU43_RS10890 (MNU43_10875)	2287175..2288101	+	927	WP_049375352.1	DUF5067 domain-containing protein	-
MNU43_RS10895 (MNU43_10880)	2288161..2289537	+	1377	WP_049375351.1	recombinase family protein	-
MNU43_RS10900 (MNU43_10885)	2289564..2290766	+	1203	Protein_2115	FAD-dependent oxidoreductase	-
MNU43_RS10905 (MNU43_10890)	2291091..2291432	-	342	WP_002438738.1	DUF1450 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2245192..2289537	44345

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18173.78 Da
• Isoelectric Point: 6.6972

>T237794 WP_021298894.1 NZ_CP093205:2286695-2287156 [Staphylococcus epidermidis]
MGLYEEICIDNDMVEIKETNKLPSFQSGFYMNGTVYIKSDLSEKEKIKVLYEELAHHKLTYGNILDQSKWINRKFENYAR
RHGYEAALPIRIIVEAHHYGVSNLYELAQYVQLSEEHVLEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T237794 NZ_LR882952:1124257-1124592 [Planktothrix agardhii]
ATGAATTTTTGGATTGATGCCCAACTTCCTCCAAGTTTAGCTAATTGGTTGGTCGAAACTTTTAATGTTAATGCTACGGC
TATTAGAGATTTGGGGTTACGAGATGCTGAAGATATAGAGATTTTCAATGCTGCCAGGAACCCAGGGACGGTTATTGTTA
GTAAAGACAGCGATTTTGTGGAGTTAGTTACTCGTTTAGGAACTCCTCCTCAAATTCTCTGGTTGACTTGTGGGAATGTT
ACTAACCGAAACCTGCGACTGATTTTGAGCAATACTTTTGCCGAAGCATTACCAATGCTAGAAGCTGGAGAAGCGATTGT
GGAAATTAGCGATTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12667.26 Da
• Isoelectric Point: 4.9783

>AT237794 WP_002493408.1 NZ_CP093205:2286354-2286683 [Staphylococcus epidermidis]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFANALHISTEYLLGFNGSEQTRQQDTM
AAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Nucleotide

• Length: 330 bp

>AT237794 NZ_LR882952:1124030-1124260 [Planktothrix agardhii]
ATGACTGCAAAAAGCTTGCTTAATCGAATTACTTATAACCCCAGGCAATGTGGAGGGAGACCTTGCATTCGAGGAATGCG
AATTCGCGTTTCTGATATTTTAGAGATGCTGGCAGAAAATGTTAGTAGTGGGGAAATTTTAGAAGATTTCCCCGACTTGG
AGGCGGAGGATATTCAAGCTTGTTTGTTGTTTGCTGCCCGACGAACTAATATTCCTAAATTAACAGTATGA