Detailed information of TA system TA237793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2021708..2022178
• Replicon: chromosome
• Accession: NZ_CP093205
• Organism: Staphylococcus epidermidis strain TSM-36

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU43_RS09480
• Protein ID: WP_001829569.1
• Coordinates: 2021990..2022178 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU43_RS09475
• Protein ID: WP_002438963.1
• Coordinates: 2021708..2021965 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU43_RS09440 (MNU43_09425)	2016995..2017150	-	156	WP_001829648.1	hypothetical protein	-
MNU43_RS09445 (MNU43_09430)	2017162..2017349	-	188	Protein_1826	hypothetical protein	-
MNU43_RS09450 (MNU43_09435)	2017500..2018678	-	1179	WP_203351816.1	IS110-like element ISSep2 family transposase	-
MNU43_RS09455 (MNU43_09440)	2019296..2019796	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU43_RS09460 (MNU43_09445)	2020067..2020654	-	588	WP_002469329.1	histidine phosphatase family protein	-
MNU43_RS09465 (MNU43_09450)	2020868..2021104	+	237	WP_002457224.1	hypothetical protein	-
MNU43_RS09470 (MNU43_09455)	2021096..2021299	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU43_RS09475 (MNU43_09460)	2021708..2021965	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU43_RS09480 (MNU43_09465)	2021990..2022178	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU43_RS09485 (MNU43_09470)	2022368..2022922	+	555	WP_002469327.1	lipoprotein N-acylation protein LnsA	-
MNU43_RS09490 (MNU43_09475)	2022982..2023215	-	234	WP_001829664.1	hypothetical protein	-
MNU43_RS09495 (MNU43_09480)	2023499..2024245	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU43_RS09500 (MNU43_09485)	2024344..2024628	+	285	WP_001829635.1	hypothetical protein	-
MNU43_RS09505 (MNU43_09490)	2024652..2024876	+	225	WP_001829613.1	hypothetical protein	-
MNU43_RS09510 (MNU43_09495)	2025497..2025697	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-45)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237793 WP_001829569.1 NZ_CP093205:2021990-2022178 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237793 NZ_LR882950:4545526-4545924 [Planktothrix agardhii]
GTGAAATTATTGTTGGATACCCAATGCTGGTTGTGGTGGTTTGCTCAACCTGAGCGATTAAATCAGGAAGTGATCGCACA
GATTGCCGATGAAAGCAATGAATTATGGTTTTCTGTTGCTAGTGTTTGGGAAATTGGGATCAAAGTTGCGATCAGAAAAT
TACCATTGCCAGAGCCAATAGATACCTACATTTCTAGTCGTATGGTGCAGTTAGATATGCGATATTTAGAAATCACAGCA
CCTCATGCACTGCGATCATCTGCGTTACCATTACATCATCGAGATCCCTTTGATCGAATGTTGATTGCTCAAGCTCAAAT
TGATAATATGACGCTGGTGAGTGCTGATTCAATATTCAAGCAATACAGCGATATTTCTGTTCTTTGGGCTGCTAATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237793 WP_002438963.1 NZ_CP093205:2021708-2021965 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237793 NZ_LR882950:4545268-4545513 [Planktothrix agardhii]
ATGGCTAAACTTCAGATTGAAAACTTACCCAACGACTTCAAAAAAAATCTCTCTGAGTTATTGTCTCGTGTAGAACTTGG
AGAAGAAATTATTATTTCCAATCAAGGGGTGGCGATCGCGAAGTTAATTCCGTTTCGTCCTTCATCCAATCGACGGGCGA
GTTTAGGGCAAGATCAAGGTAAATTTATCATACCAGACGACTTTAATGAACCGTTACCCCAAGAAATTTTGGCAGCATTT
GAATGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3