Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 912014..912543 Replicon chromosome
Accession NZ_CP093205
Organism Staphylococcus epidermidis strain TSM-36

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU43_RS04190 Protein ID WP_001829891.1
Coordinates 912181..912543 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU43_RS04185 Protein ID WP_001829931.1
Coordinates 912014..912184 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU43_RS04160 (MNU43_04155) 907838..908317 + 480 WP_002457111.1 PH domain-containing protein -
MNU43_RS04165 (MNU43_04160) 908310..909815 + 1506 WP_002457110.1 PH domain-containing protein -
MNU43_RS04170 (MNU43_04165) 909802..910311 + 510 WP_002457109.1 PH domain-containing protein -
MNU43_RS04175 (MNU43_04170) 910359..910712 + 354 WP_002457108.1 holo-ACP synthase -
MNU43_RS04180 (MNU43_04175) 910779..911927 + 1149 WP_002457107.1 alanine racemase -
MNU43_RS04185 (MNU43_04180) 912014..912184 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU43_RS04190 (MNU43_04185) 912181..912543 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU43_RS04195 (MNU43_04190) 912888..913889 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU43_RS04200 (MNU43_04195) 913989..914315 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU43_RS04205 (MNU43_04200) 914317..914790 + 474 WP_002469585.1 anti-sigma B factor RsbW -
MNU43_RS04210 (MNU43_04205) 914765..915535 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237791 WP_001829891.1 NZ_CP093205:912181-912543 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237791 NZ_LR882950:c4508979-4508716 [Planktothrix agardhii]
ATGAGTAACCGCATATTAGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAGACTCT
CAAAAAAATTAATAAACTGCTAGATGCAATCAAAAAACGTCCCTTTGAAGGAATTGGTAAACCTGAACCTTTGAAAGAAA
ATTTATCTGGTTTTTGGTCACGTCGTATTGATGATACTAATCGTCTAGTTTACGTTGTCGATGATCTCTATATCACGATC
ATTTCTTGTCGTTATCATTATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237791 WP_001829931.1 NZ_CP093205:912014-912184 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237791 NZ_LR882950:c4509226-4508972 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References