Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 900829..901338 Replicon chromosome
Accession NZ_CP093205
Organism Staphylococcus epidermidis strain TSM-36

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU43_RS04130 Protein ID WP_001829980.1
Coordinates 901129..901338 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU43_RS04125 Protein ID WP_001829893.1
Coordinates 900829..901122 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU43_RS04100 (MNU43_04095) 895837..896625 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MNU43_RS04105 (MNU43_04100) 896631..897269 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU43_RS04110 (MNU43_04105) 897358..898230 + 873 WP_002470121.1 membrane protein insertase YidC -
MNU43_RS04115 (MNU43_04110) 898336..898989 - 654 WP_001829983.1 HD domain-containing protein -
MNU43_RS04120 (MNU43_04115) 899171..900655 - 1485 WP_002457116.1 cardiolipin synthase -
MNU43_RS04125 (MNU43_04120) 900829..901122 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU43_RS04130 (MNU43_04125) 901129..901338 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU43_RS04135 (MNU43_04130) 901481..901618 + 138 WP_001829949.1 Lmo0850 family protein -
MNU43_RS04140 (MNU43_04135) 901717..902928 - 1212 WP_002457115.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU43_RS04145 (MNU43_04140) 903319..904392 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MNU43_RS04150 (MNU43_04145) 904404..905759 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237790 WP_001829980.1 NZ_CP093205:901129-901338 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237790 NZ_LR882950:c3312270-3312082 [Planktothrix agardhii]
ATGAAAGTAAAAGATATTATTAAACGATTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATT
TAAACATCCTGTAAAATCTGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTA
TTATTAAACAAGCTCAAATTAATCTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237790 WP_001829893.1 NZ_CP093205:900829-901122 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237790 NZ_LR882950:c3312061-3311852 [Planktothrix agardhii]
ATGAAACGTTATGCAATTGTTATTGAAAAAGCGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACGGGTTACACCATAGAAGAAATTGAAACAGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GTTTACCGATTCCTGAACCTGTGGCTATATCCGAATATGTTGAAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References