Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 900829..901338 | Replicon | chromosome |
Accession | NZ_CP093205 | ||
Organism | Staphylococcus epidermidis strain TSM-36 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | Q5HMD5 |
Locus tag | MNU43_RS04130 | Protein ID | WP_001829980.1 |
Coordinates | 901129..901338 (+) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | Q5HMD4 |
Locus tag | MNU43_RS04125 | Protein ID | WP_001829893.1 |
Coordinates | 900829..901122 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU43_RS04100 (MNU43_04095) | 895837..896625 | + | 789 | WP_002469583.1 | hydroxyethylthiazole kinase | - |
MNU43_RS04105 (MNU43_04100) | 896631..897269 | + | 639 | WP_002505076.1 | thiamine phosphate synthase | - |
MNU43_RS04110 (MNU43_04105) | 897358..898230 | + | 873 | WP_002470121.1 | membrane protein insertase YidC | - |
MNU43_RS04115 (MNU43_04110) | 898336..898989 | - | 654 | WP_001829983.1 | HD domain-containing protein | - |
MNU43_RS04120 (MNU43_04115) | 899171..900655 | - | 1485 | WP_002457116.1 | cardiolipin synthase | - |
MNU43_RS04125 (MNU43_04120) | 900829..901122 | + | 294 | WP_001829893.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
MNU43_RS04130 (MNU43_04125) | 901129..901338 | + | 210 | WP_001829980.1 | heavy-metal-associated domain-containing protein | Toxin |
MNU43_RS04135 (MNU43_04130) | 901481..901618 | + | 138 | WP_001829949.1 | Lmo0850 family protein | - |
MNU43_RS04140 (MNU43_04135) | 901717..902928 | - | 1212 | WP_002457115.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
MNU43_RS04145 (MNU43_04140) | 903319..904392 | + | 1074 | WP_002468311.1 | D-alanine--D-alanine ligase | - |
MNU43_RS04150 (MNU43_04145) | 904404..905759 | + | 1356 | WP_002457113.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7987.24 Da Isoelectric Point: 7.0080
>T237790 WP_001829980.1 NZ_CP093205:901129-901338 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
Download Length: 210 bp
>T237790 NZ_LR882950:c3312270-3312082 [Planktothrix agardhii]
ATGAAAGTAAAAGATATTATTAAACGATTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATT
TAAACATCCTGTAAAATCTGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTA
TTATTAAACAAGCTCAAATTAATCTTTAA
ATGAAAGTAAAAGATATTATTAAACGATTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATT
TAAACATCCTGTAAAATCTGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTA
TTATTAAACAAGCTCAAATTAATCTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11070.65 Da Isoelectric Point: 5.5778
>AT237790 WP_001829893.1 NZ_CP093205:900829-901122 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
Download Length: 294 bp
>AT237790 NZ_LR882950:c3312061-3311852 [Planktothrix agardhii]
ATGAAACGTTATGCAATTGTTATTGAAAAAGCGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACGGGTTACACCATAGAAGAAATTGAAACAGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GTTTACCGATTCCTGAACCTGTGGCTATATCCGAATATGTTGAAGTTTAA
ATGAAACGTTATGCAATTGTTATTGAAAAAGCGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACGGGTTACACCATAGAAGAAATTGAAACAGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GTTTACCGATTCCTGAACCTGTGGCTATATCCGAATATGTTGAAGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HWU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0N1EPA7 |