Detailed information of TA system TA237789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1991063..1991533
• Replicon: chromosome
• Accession: NZ_CP093202
• Organism: Staphylococcus epidermidis strain TSM-31

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU47_RS09370
• Protein ID: WP_001829569.1
• Coordinates: 1991345..1991533 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU47_RS09365
• Protein ID: WP_002438963.1
• Coordinates: 1991063..1991320 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU47_RS09330 (MNU47_09320)	1986350..1986505	-	156	WP_001829648.1	hypothetical protein	-
MNU47_RS09335 (MNU47_09325)	1986517..1986704	-	188	Protein_1805	hypothetical protein	-
MNU47_RS09340 (MNU47_09330)	1986855..1988033	-	1179	WP_104832443.1	IS110 family transposase	-
MNU47_RS09345 (MNU47_09335)	1988651..1989151	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU47_RS09350 (MNU47_09340)	1989422..1990009	-	588	WP_002469329.1	histidine phosphatase family protein	-
MNU47_RS09355 (MNU47_09345)	1990223..1990459	+	237	WP_002457224.1	hypothetical protein	-
MNU47_RS09360 (MNU47_09350)	1990451..1990654	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU47_RS09365 (MNU47_09355)	1991063..1991320	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU47_RS09370 (MNU47_09360)	1991345..1991533	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU47_RS09375 (MNU47_09365)	1991723..1992277	+	555	WP_002469327.1	lipoprotein N-acylation protein LnsA	-
MNU47_RS09380 (MNU47_09370)	1992337..1992570	-	234	WP_001829664.1	hypothetical protein	-
MNU47_RS09385 (MNU47_09375)	1992854..1993600	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU47_RS09390 (MNU47_09380)	1993699..1993983	+	285	WP_001829635.1	hypothetical protein	-
MNU47_RS09395 (MNU47_09385)	1994007..1994231	+	225	WP_001829613.1	hypothetical protein	-
MNU47_RS09400 (MNU47_09390)	1994852..1995052	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

• CopG antitoxin (3-68)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237789 WP_001829569.1 NZ_CP093202:1991345-1991533 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237789 NZ_LR882950:c2822512-2822240 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237789 WP_002438963.1 NZ_CP093202:1991063-1991320 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237789 NZ_LR882950:c2822259-2822035 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3