237788

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1850247..1851049 Replicon chromosome
Accession NZ_CP093202
Organism Staphylococcus epidermidis strain TSM-31

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MNU47_RS08620 Protein ID WP_002469232.1
Coordinates 1850588..1851049 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MNU47_RS08615 Protein ID WP_002439260.1
Coordinates 1850247..1850576 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU47_RS08565 (MNU47_08560) 1845306..1845521 + 216 WP_001831694.1 NINE protein -
MNU47_RS08570 (MNU47_08565) 1846064..1846594 + 531 WP_002475755.1 N-acetyltransferase -
MNU47_RS08575 (MNU47_08570) 1847368..1847601 - 234 Protein_1655 ATP-binding protein -
MNU47_RS08580 (MNU47_08575) 1847980..1848207 + 228 WP_002505719.1 DUF2188 domain-containing protein -
MNU47_RS08585 (MNU47_08580) 1848204..1848407 - 204 WP_002505718.1 hypothetical protein -
MNU47_RS08590 (MNU47_08585) 1848422..1848634 - 213 Protein_1658 DUF771 domain-containing protein -
MNU47_RS08595 (MNU47_08590) 1848638..1849393 - 756 Protein_1659 phage regulatory protein/antirepressor Ant -
MNU47_RS08600 (MNU47_08595) 1849443..1849649 + 207 WP_002439266.1 hypothetical protein -
MNU47_RS08605 (MNU47_08600) 1849638..1849802 - 165 WP_002439265.1 hypothetical protein -
MNU47_RS08610 (MNU47_08605) 1849799..1850053 - 255 WP_002505715.1 helix-turn-helix transcriptional regulator -
MNU47_RS08615 (MNU47_08610) 1850247..1850576 + 330 WP_002439260.1 helix-turn-helix transcriptional regulator Antitoxin
MNU47_RS08620 (MNU47_08615) 1850588..1851049 + 462 WP_002469232.1 ImmA/IrrE family metallo-endopeptidase Toxin
MNU47_RS08625 (MNU47_08620) 1851065..1851583 + 519 WP_002505714.1 hypothetical protein -
MNU47_RS08630 (MNU47_08625) 1851585..1852028 + 444 WP_002439254.1 hypothetical protein -
MNU47_RS08635 (MNU47_08630) 1852101..1852295 + 195 WP_002439253.1 hypothetical protein -
MNU47_RS08640 (MNU47_08635) 1852364..1852879 + 516 WP_002439252.1 hypothetical protein -
MNU47_RS08645 (MNU47_08640) 1852881..1853216 + 336 WP_002439251.1 hypothetical protein -
MNU47_RS08650 (MNU47_08645) 1853272..1853670 + 399 Protein_1670 phage integrase SAM-like domain-containing protein -
MNU47_RS08655 (MNU47_08650) 1853776..1854246 + 471 Protein_1671 site-specific integrase -
MNU47_RS08670 (MNU47_08665) 1854843..1855418 - 576 WP_001829272.1 competence protein ComK -
MNU47_RS08675 (MNU47_08670) 1855633..1855851 + 219 WP_001829292.1 IDEAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1844519..1854336 9817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(25-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18327.03 Da        Isoelectric Point: 6.8511

>T237788 WP_002469232.1 NZ_CP093202:1850588-1851049 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYEAALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T237788 NZ_LR882950:2531998-2532282 [Planktothrix agardhii]
ATGCCTCAAAAATATAAAGACAAACGCACAGCCAAATTTGCTGCTGGCGATCGTGTCAAAGAATTTCAGGCATTTGAAAG
ACAAGCATACAAGCGCCTAGAAATCCTAGAAGCCGCACCTAATAAAGAATCCTTAAAGGCTTTGCCAAGTAATCGTTTTG
AGGCACTAGGCGGAGATAGAAAAGGGCAGTACAGCATCCGCATAAATGACAAGTGGCGTATTTGTTTTGAGTGGACAGAA
ACAGAAAATCGCCCATTTCATATCGAAATTGTCGATTATCACTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT237788 WP_002439260.1 NZ_CP093202:1850247-1850576 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT237788 NZ_LR882950:2532297-2532611 [Planktothrix agardhii]
ATGGCAAGACCTGCAATTCACCCTGGCGAAATCTTATCTGATGAACTAGAAGAACTGGGAATTAGTGCATCAGAACTAGC
GCGATCGCTCCATATACCCACAAATCGGATTACGCAAATTCTCAAAGGGCAAAGAGGTATTACTGCTGACACGGCATTAC
GTCTAGGACGATGGTTTGGCACTGGTGCAGAACTATGGCTTAATTTGCAAAAAACTTATGAGTTACGCCTAGCCCAAGAG
TTAGCGGGAGAAGAAATTCAAAATACAATTCAACCTCGTTCATCTATCAACAATCAGCCGTTAGTTCAAGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References