Detailed information of TA system TA237787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 984817..985619
• Replicon: chromosome
• Accession: NZ_CP093202
• Organism: Staphylococcus epidermidis strain TSM-31

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: MNU47_RS04710
• Protein ID: WP_002468490.1
• Coordinates: 985440..985619 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MNU47_RS04705
• Protein ID: WP_002486232.1
• Coordinates: 984817..985416 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU47_RS04680 (MNU47_04675)	980029..981486	+	1458	WP_002440300.1	ABC transporter substrate-binding protein/permease	-
MNU47_RS04685 (MNU47_04680)	981479..982201	+	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
MNU47_RS04690 (MNU47_04685)	982698..982847	+	150	WP_002468809.1	hypothetical protein	-
MNU47_RS04695 (MNU47_04690)	983062..984192	+	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
MNU47_RS04700 (MNU47_04695)	984189..984659	+	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MNU47_RS04705 (MNU47_04700)	984817..985416	+	600	WP_002486232.1	glucosamine-6-phosphate isomerase	Antitoxin
MNU47_RS04710 (MNU47_04705)	985440..985619	+	180	WP_002468490.1	SAS053 family protein	Toxin
MNU47_RS04715 (MNU47_04710)	985775..986179	+	405	WP_002485605.1	hypothetical protein	-
MNU47_RS04720 (MNU47_04715)	986364..987749	+	1386	WP_001829862.1	class II fumarate hydratase	-
MNU47_RS04725 (MNU47_04720)	988110..988934	-	825	WP_001829804.1	RluA family pseudouridine synthase	-
MNU47_RS04730 (MNU47_04725)	989093..990226	+	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T237787 WP_002468490.1 NZ_CP093202:985440-985619 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T237787 NZ_LR882950:c1355925-1355590 [Planktothrix agardhii]
ATGAATTTTTGGATTGATGCCCAACTTCCTCCAAGTTTAGCTAATTGGTTGGTCGAAACTTTTAATGTTAATGCTACGGC
TATTAGAGATTTGGGGTTACGAGATGCTGAAGATATAGAGATTTTCAATGCTGCCAGGAACCCAGGGACGGTTATTGTTA
GTAAAGACAGCGATTTTGTGGAGTTAGTTACTCGTTTAGGAACTCCTCCTCAAATTCTCTGGTTGACTTGTGGGAATGTT
ACTAACCGAAACCTGCGACTGATTTTGAGCAATACTTTTGCCGAAGCATTACCAATGCTAGAAGCTGGAGAAGCGATTGT
GGAAATTAGCGATTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22695.55 Da
• Isoelectric Point: 4.8641

>AT237787 WP_002486232.1 NZ_CP093202:984817-985416 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT237787 NZ_LR882950:c1356152-1355922 [Planktothrix agardhii]
ATGACTGCAAAAAGCTTGCTTAATCGAATTACTTATAACCCCAGGCAATGTGGAGGGAGACCTTGCATTCGAGGAATGCG
AATTCGCGTTTCTGATATTTTAGAGATGCTGGCAGAAAATGTTAGTAGTGGGGAAATTTTAGAAGATTTCCCCGACTTGG
AGGCGGAGGATATTCAAGCTTGTTTGTTGTTTGCTGCCCGACGAACTAATATTCCTAAATTAACAGTATGA

Structures

Toxin

• AlphaFold DB: A0A2G7HY44