Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 843790..844319 Replicon chromosome
Accession NZ_CP093202
Organism Staphylococcus epidermidis strain TSM-31

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU47_RS03900 Protein ID WP_001829891.1
Coordinates 843957..844319 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU47_RS03895 Protein ID WP_001829931.1
Coordinates 843790..843960 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU47_RS03870 (MNU47_03865) 839614..840093 + 480 WP_002457111.1 PH domain-containing protein -
MNU47_RS03875 (MNU47_03870) 840086..841591 + 1506 WP_002505951.1 PH domain-containing protein -
MNU47_RS03880 (MNU47_03875) 841578..842087 + 510 WP_002457109.1 PH domain-containing protein -
MNU47_RS03885 (MNU47_03880) 842135..842488 + 354 WP_002457108.1 holo-ACP synthase -
MNU47_RS03890 (MNU47_03885) 842555..843703 + 1149 WP_002457107.1 alanine racemase -
MNU47_RS03895 (MNU47_03890) 843790..843960 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU47_RS03900 (MNU47_03895) 843957..844319 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU47_RS03905 (MNU47_03900) 844664..845665 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU47_RS03910 (MNU47_03905) 845765..846091 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU47_RS03915 (MNU47_03910) 846093..846572 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU47_RS03920 (MNU47_03915) 846547..847317 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237786 WP_001829891.1 NZ_CP093202:843957-844319 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237786 NZ_LR882944:c3246141-3245869 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237786 WP_001829931.1 NZ_CP093202:843790-843960 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237786 NZ_LR882944:c3245888-3245664 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References