Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 832605..833114 Replicon chromosome
Accession NZ_CP093202
Organism Staphylococcus epidermidis strain TSM-31

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU47_RS03840 Protein ID WP_001829980.1
Coordinates 832905..833114 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU47_RS03835 Protein ID WP_001829893.1
Coordinates 832605..832898 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU47_RS03810 (MNU47_03805) 827613..828401 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MNU47_RS03815 (MNU47_03810) 828407..829045 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU47_RS03820 (MNU47_03815) 829134..830006 + 873 WP_002470121.1 membrane protein insertase YidC -
MNU47_RS03825 (MNU47_03820) 830112..830765 - 654 WP_001829983.1 HD domain-containing protein -
MNU47_RS03830 (MNU47_03825) 830947..832431 - 1485 WP_002457116.1 cardiolipin synthase -
MNU47_RS03835 (MNU47_03830) 832605..832898 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU47_RS03840 (MNU47_03835) 832905..833114 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU47_RS03845 (MNU47_03840) 833257..833394 + 138 WP_001829949.1 Lmo0850 family protein -
MNU47_RS03850 (MNU47_03845) 833493..834704 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU47_RS03855 (MNU47_03850) 835095..836168 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MNU47_RS03860 (MNU47_03855) 836180..837535 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237785 WP_001829980.1 NZ_CP093202:832905-833114 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237785 NZ_LR882944:c1809758-1809423 [Planktothrix agardhii]
ATGAATTTTTGGATTGATGCCCAACTTCCTCCAAGTTTAGCTAATTGGTTGGTCGAAACTTTTAATGTTAATGCTACGGC
TATTAGAGATTTGGGGTTACGAGATGCTGAAGATATAGAGATTTTCAATGCTGCCAGGAACCCAGGGACGGTTATTGTTA
GTAAAGACAGCGATTTTGTGGAGTTAGTTACTCGTTTAGGAACTCCTCCTCAAATTCTCTGGTTGACTTGTGGGAATGTT
ACTAACCGAAACCTGCGACTGATTTTGAGCAATACTTTTGCCGAAGCATTACCAATGCTAGAAGCTGGAGAAGCGATTGT
GGAAATTAGCGATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237785 WP_001829893.1 NZ_CP093202:832605-832898 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237785 NZ_LR882944:c1809985-1809755 [Planktothrix agardhii]
ATGACTGCAAAAAGCTTGCTTAATCGAATTACTTATAACCCCAGGCAATGTGGAGGGAGACCTTGCATTCGAGGGATGCG
AATTCGCGTTTCTGATATTTTAGAGATGCTGGCAGAAAATGTTAGTAGTGGGGAAATTTTAGAAGATTTCCCCGACTTGG
AGGCGGAGGATATTCAAGCTTGTTTGTTGTTTGCTGCCCGACGAACTAATATTCCTAAATTAACAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References