Detailed information of TA system TA237784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2108343..2108813
• Replicon: chromosome
• Accession: NZ_CP093198
• Organism: Staphylococcus epidermidis strain TSM-18

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU36_RS10325
• Protein ID: WP_001829569.1
• Coordinates: 2108625..2108813 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU36_RS10320
• Protein ID: WP_002438963.1
• Coordinates: 2108343..2108600 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU36_RS10280 (MNU36_10280)	2103707..2104423	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
MNU36_RS10285 (MNU36_10285)	2104584..2105006	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
MNU36_RS10290 (MNU36_10290)	2105190..2105345	-	156	WP_001829648.1	hypothetical protein	-
MNU36_RS10295 (MNU36_10295)	2105357..2105544	-	188	Protein_1997	hypothetical protein	-
MNU36_RS10300 (MNU36_10300)	2105931..2106431	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU36_RS10305 (MNU36_10305)	2106702..2107289	-	588	WP_001829615.1	histidine phosphatase family protein	-
MNU36_RS10310 (MNU36_10310)	2107503..2107739	+	237	WP_002457224.1	hypothetical protein	-
MNU36_RS10315 (MNU36_10315)	2107731..2107934	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU36_RS10320 (MNU36_10320)	2108343..2108600	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU36_RS10325 (MNU36_10325)	2108625..2108813	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU36_RS10330 (MNU36_10330)	2109003..2109557	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
MNU36_RS10335 (MNU36_10335)	2109617..2109850	-	234	WP_001829664.1	hypothetical protein	-
MNU36_RS10340 (MNU36_10340)	2110134..2110880	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU36_RS10345 (MNU36_10345)	2110979..2111263	+	285	WP_001829635.1	hypothetical protein	-
MNU36_RS10350 (MNU36_10350)	2111287..2111511	+	225	WP_001829613.1	hypothetical protein	-
MNU36_RS10355 (MNU36_10355)	2112132..2112332	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2099315..2127025	27710
	-	flank	IS/Tn	-	-	2105190..2105345	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (9-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-65)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237784 WP_001829569.1 NZ_CP093198:2108625-2108813 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237784 NZ_LR882944:c1452203-1451982 [Planktothrix agardhii]
ATGAGTAAATTGCCTAGAATTTCAGGTAAGGAATGTGTTAAAGCTTTAGAGAAAGTGGGTTTTTATCTAAGACGACAACA
AGGTAGCCATCTGATTCTCAGACGTAATGAACCTTTAACACAAGTCGTTGTTCCAAATCATTCCGAACTGGATAAAGGAA
CTTTAAGATCAATTATTAGAGGTGCTGGCTTAAGTGTCGATGATTTTATACAATTATTGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237784 WP_002438963.1 NZ_CP093198:2108343-2108600 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237784 NZ_LR882944:c1452418-1452200 [Planktothrix agardhii]
ATGATTAGACGAGTAACAATTTATTCCGGTGAGGATGGTTACTGGGTGGTTGAATGTCCGAGTTTACCCGGTTGTGTAAG
TCAGGGGAAAACCCAAGAAGAAGCATTAATCAATATTAAAGAAGCAATTCAAGGATATATTTTAGCGTTAGAAGAAGATG
GTTTACCTGTACCCCTCGAAAATGTTGAGACTTTAGAAAATTTACTGTTAGTGGTATGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3