Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 768976..769505 Replicon chromosome
Accession NZ_CP093198
Organism Staphylococcus epidermidis strain TSM-18

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU36_RS03585 Protein ID WP_001829891.1
Coordinates 769143..769505 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU36_RS03580 Protein ID WP_001829931.1
Coordinates 768976..769146 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU36_RS03555 (MNU36_03555) 764801..765280 + 480 WP_001829909.1 PH domain-containing protein -
MNU36_RS03560 (MNU36_03560) 765273..766778 + 1506 WP_001829976.1 PH domain-containing protein -
MNU36_RS03565 (MNU36_03565) 766765..767274 + 510 WP_001829888.1 PH domain-containing protein -
MNU36_RS03570 (MNU36_03570) 767322..767675 + 354 WP_001829915.1 holo-ACP synthase -
MNU36_RS03575 (MNU36_03575) 767741..768889 + 1149 WP_002468951.1 alanine racemase -
MNU36_RS03580 (MNU36_03580) 768976..769146 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU36_RS03585 (MNU36_03585) 769143..769505 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU36_RS03590 (MNU36_03590) 769851..770852 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU36_RS03595 (MNU36_03595) 770952..771278 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU36_RS03600 (MNU36_03600) 771280..771759 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU36_RS03605 (MNU36_03605) 771734..772504 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237781 WP_001829891.1 NZ_CP093198:769143-769505 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237781 NZ_LR882944:c221086-220937 [Planktothrix agardhii]
ATGAGTAACCGCATATTAGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237781 WP_001829931.1 NZ_CP093198:768976-769146 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237781 NZ_LR882944:c221288-221079 [Planktothrix agardhii]
GTGTTAGATCGGGTAGTTGAAGATGCTGACTACACCATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCT
TGATTATTTTAATGGTTTACTGGAAACGGTTCATTTATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTG
CCCAATATAGGCAGGGGAAAGCTCTTGAACATCAGTTGATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References