Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 757793..758302 Replicon chromosome
Accession NZ_CP093198
Organism Staphylococcus epidermidis strain TSM-18

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU36_RS03525 Protein ID WP_001829980.1
Coordinates 758093..758302 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU36_RS03520 Protein ID WP_001829893.1
Coordinates 757793..758086 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU36_RS03495 (MNU36_03495) 752801..753589 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MNU36_RS03500 (MNU36_03500) 753595..754233 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU36_RS03505 (MNU36_03505) 754322..755194 + 873 WP_002458703.1 membrane protein insertase YidC -
MNU36_RS03510 (MNU36_03510) 755300..755953 - 654 WP_001829983.1 HD domain-containing protein -
MNU36_RS03515 (MNU36_03515) 756135..757619 - 1485 WP_002457116.1 cardiolipin synthase -
MNU36_RS03520 (MNU36_03520) 757793..758086 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU36_RS03525 (MNU36_03525) 758093..758302 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU36_RS03530 (MNU36_03530) 758445..758582 + 138 WP_001829949.1 Lmo0850 family protein -
MNU36_RS03535 (MNU36_03535) 758682..759893 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU36_RS03540 (MNU36_03540) 760284..761357 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU36_RS03545 (MNU36_03545) 761369..762724 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237780 WP_001829980.1 NZ_CP093198:758093-758302 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237780 NZ_CP093198:758093-758302 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237780 WP_001829893.1 NZ_CP093198:757793-758086 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237780 NZ_CP093198:757793-758086 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References