Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2140994..2141464 Replicon chromosome
Accession NZ_CP093196
Organism Staphylococcus epidermidis strain TMDU-2014-62

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MNU55_RS10365 Protein ID WP_001829569.1
Coordinates 2141276..2141464 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MNU55_RS10360 Protein ID WP_002438963.1
Coordinates 2140994..2141251 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU55_RS10320 (MNU55_10320) 2136358..2137074 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MNU55_RS10325 (MNU55_10325) 2137235..2137657 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MNU55_RS10330 (MNU55_10330) 2137841..2137978 - 138 WP_162161215.1 hypothetical protein -
MNU55_RS10335 (MNU55_10335) 2138008..2138195 - 188 Protein_2005 hypothetical protein -
MNU55_RS10340 (MNU55_10340) 2138582..2139082 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MNU55_RS10345 (MNU55_10345) 2139353..2139940 - 588 WP_001829615.1 histidine phosphatase family protein -
MNU55_RS10350 (MNU55_10350) 2140154..2140390 + 237 WP_002457224.1 hypothetical protein -
MNU55_RS10355 (MNU55_10355) 2140382..2140585 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
MNU55_RS10360 (MNU55_10360) 2140994..2141251 + 258 WP_002438963.1 hypothetical protein Antitoxin
MNU55_RS10365 (MNU55_10365) 2141276..2141464 + 189 WP_001829569.1 hypothetical protein Toxin
MNU55_RS10370 (MNU55_10370) 2141654..2142208 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MNU55_RS10375 (MNU55_10375) 2142268..2142501 - 234 WP_001829664.1 hypothetical protein -
MNU55_RS10380 (MNU55_10380) 2142785..2143531 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
MNU55_RS10385 (MNU55_10385) 2143630..2143914 + 285 WP_001829635.1 hypothetical protein -
MNU55_RS10390 (MNU55_10390) 2143938..2144162 + 225 WP_001829613.1 hypothetical protein -
MNU55_RS10395 (MNU55_10395) 2144783..2144983 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2137841..2144983 7142
- flank IS/Tn - - 2137841..2137996 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin

CopG antitoxin

(3-68)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T237779 WP_001829569.1 NZ_CP093196:2141276-2141464 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T237779 NZ_LR882938:c3541451-3541179 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT237779 WP_002438963.1 NZ_CP093196:2140994-2141251 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT237779 NZ_LR882938:c3541198-3540974 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References