Detailed information of TA system TA237778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1994583..1995386
• Replicon: chromosome
• Accession: NZ_CP093196
• Organism: Staphylococcus epidermidis strain TMDU-2014-62

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU55_RS09610
• Protein ID: WP_002484735.1
• Coordinates: 1994925..1995386 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU55_RS09605
• Protein ID: WP_002484747.1
• Coordinates: 1994583..1994912 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU55_RS09575 (MNU55_09575)	1989595..1990518	-	924	WP_059223500.1	recombinase RecT	-
MNU55_RS09580 (MNU55_09580)	1990520..1992472	-	1953	WP_194086741.1	AAA family ATPase	-
MNU55_RS09585 (MNU55_09585)	1992805..1993071	+	267	WP_002456364.1	hypothetical protein	-
MNU55_RS09590 (MNU55_09590)	1993198..1993407	-	210	WP_001830281.1	hypothetical protein	-
MNU55_RS09595 (MNU55_09595)	1993420..1994136	-	717	WP_002468739.1	phage repressor protein	-
MNU55_RS09600 (MNU55_09600)	1994150..1994389	-	240	WP_194086740.1	helix-turn-helix transcriptional regulator	-
MNU55_RS09605 (MNU55_09605)	1994583..1994912	+	330	WP_002484747.1	helix-turn-helix transcriptional regulator	Antitoxin
MNU55_RS09610 (MNU55_09610)	1994925..1995386	+	462	WP_002484735.1	ImmA/IrrE family metallo-endopeptidase	Toxin
MNU55_RS09615 (MNU55_09615)	1995555..1995722	+	168	WP_002497581.1	hypothetical protein	-
MNU55_RS09620 (MNU55_09620)	1995744..1996883	+	1140	WP_103422872.1	CapA family protein	-
MNU55_RS09625 (MNU55_09625)	1997068..1997619	+	552	WP_103422871.1	Ltp family lipoprotein	-
MNU55_RS09630 (MNU55_09630)	1997682..1998731	+	1050	WP_001830299.1	site-specific integrase	-
MNU55_RS09645 (MNU55_09645)	1999132..1999707	-	576	WP_254105930.1	competence protein ComK	-
MNU55_RS09650 (MNU55_09650)	1999922..2000140	+	219	WP_001829292.1	IDEAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1956624..1998731	42107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (33-121)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17881.48 Da
• Isoelectric Point: 5.0503

>T237778 WP_002484735.1 NZ_CP093196:1994925-1995386 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYGLTTRCGDYVIAFEPLRVFEYKEI

Nucleotide

• Length: 462 bp

>T237778 NZ_LR882938:2781958-2782293 [Planktothrix agardhii]
ATGAATTTTTGGATTGATGCCCAACTTCCTCCAAGTTTAGCTAATTGGTTGGTCGAAACTTTTAATGTTAATGCTACGGC
TATTAGAGATTTGGGGTTACGAGATGCTGAAGATATAGAGATTTTCAATGCTGCCAGGAACCCAGGGACGGTTATTGTTA
GTAAAGACAGCGATTTTGTGGAGTTAGTTACTCGTTTAGGAACTCCTCCTCAAATTCTCTGGTTGACTTGTGGGAATGTT
ACTAACCGAAACCTGCGACTGATTTTGAGCAATACTTTTGCCGAAGCATTACCAATGCTAGAAGCTGGAGAAGCGATTGT
GGAAATTAGCGATTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12708.21 Da
• Isoelectric Point: 4.8033

>AT237778 WP_002484747.1 NZ_CP093196:1994583-1994912 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPQH
RAAHLDGDLTDEEWQEILDYAEYIRSKRK

Nucleotide

• Length: 330 bp

>AT237778 NZ_LR882938:2781731-2781961 [Planktothrix agardhii]
ATGACTGCAAAAAGCTTGCTTAATCGAATTACTTATAACCCCAGGCAATGTGGAGGGAGACCTTGCATTCGAGGGATGCG
AATTCGCGTTTCTGATATTTTAGAGATGCTGGCAGAAAATGTTAGTAGTGGGGAAATTTTAGAAGATTTCCCCGACTTGG
AGGCGGAGGATATTCAAGCTTGTTTGTTGTTTGCTGCCCGACGAACTAATATTCCTAAATTAACAGTATGA