Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 874635..875164 Replicon chromosome
Accession NZ_CP093196
Organism Staphylococcus epidermidis strain TMDU-2014-62

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU55_RS04140 Protein ID WP_001829891.1
Coordinates 874802..875164 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU55_RS04135 Protein ID WP_001829931.1
Coordinates 874635..874805 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU55_RS04110 (MNU55_04110) 870460..870939 + 480 WP_001829909.1 PH domain-containing protein -
MNU55_RS04115 (MNU55_04115) 870932..872437 + 1506 WP_001829976.1 PH domain-containing protein -
MNU55_RS04120 (MNU55_04120) 872424..872933 + 510 WP_001829888.1 PH domain-containing protein -
MNU55_RS04125 (MNU55_04125) 872981..873334 + 354 WP_001829915.1 holo-ACP synthase -
MNU55_RS04130 (MNU55_04130) 873400..874548 + 1149 WP_002468951.1 alanine racemase -
MNU55_RS04135 (MNU55_04135) 874635..874805 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU55_RS04140 (MNU55_04140) 874802..875164 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU55_RS04145 (MNU55_04145) 875510..876511 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU55_RS04150 (MNU55_04150) 876611..876937 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU55_RS04155 (MNU55_04155) 876939..877418 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU55_RS04160 (MNU55_04160) 877393..878163 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237776 WP_001829891.1 NZ_CP093196:874802-875164 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237776 NZ_LR882938:c511213-510959 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237776 WP_001829931.1 NZ_CP093196:874635-874805 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237776 NZ_LR882938:c510966-510817 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References