Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 863452..863961 Replicon chromosome
Accession NZ_CP093196
Organism Staphylococcus epidermidis strain TMDU-2014-62

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU55_RS04080 Protein ID WP_001829980.1
Coordinates 863752..863961 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU55_RS04075 Protein ID WP_001829893.1
Coordinates 863452..863745 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU55_RS04050 (MNU55_04050) 858460..859248 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MNU55_RS04055 (MNU55_04055) 859254..859892 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU55_RS04060 (MNU55_04060) 859981..860853 + 873 WP_002458703.1 membrane protein insertase YidC -
MNU55_RS04065 (MNU55_04065) 860959..861612 - 654 WP_001829983.1 HD domain-containing protein -
MNU55_RS04070 (MNU55_04070) 861794..863278 - 1485 WP_002457116.1 cardiolipin synthase -
MNU55_RS04075 (MNU55_04075) 863452..863745 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU55_RS04080 (MNU55_04080) 863752..863961 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU55_RS04085 (MNU55_04085) 864104..864241 + 138 WP_001829949.1 Lmo0850 family protein -
MNU55_RS04090 (MNU55_04090) 864341..865552 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU55_RS04095 (MNU55_04095) 865943..867016 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU55_RS04100 (MNU55_04100) 867028..868383 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237775 WP_001829980.1 NZ_CP093196:863752-863961 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237775 NZ_LR882938:c510966-510817 [Planktothrix agardhii]
ATGAGTAATCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237775 WP_001829893.1 NZ_CP093196:863452-863745 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237775 NZ_LR882938:c511213-510959 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References