Detailed information of TA system TA237774

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1974884..1975354
• Replicon: chromosome
• Accession: NZ_CP093193
• Organism: Staphylococcus epidermidis strain TMDU-323

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU37_RS09330
• Protein ID: WP_001829569.1
• Coordinates: 1975166..1975354 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU37_RS09325
• Protein ID: WP_002438963.1
• Coordinates: 1974884..1975141 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU37_RS09290 (MNU37_09280)	1970171..1970326	-	156	WP_001829648.1	hypothetical protein	-
MNU37_RS09295 (MNU37_09285)	1970338..1970525	-	188	Protein_1797	hypothetical protein	-
MNU37_RS09300 (MNU37_09290)	1970676..1971854	-	1179	WP_104832443.1	IS110 family transposase	-
MNU37_RS09305 (MNU37_09295)	1972472..1972972	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU37_RS09310 (MNU37_09300)	1973243..1973830	-	588	WP_002469329.1	histidine phosphatase family protein	-
MNU37_RS09315 (MNU37_09305)	1974044..1974280	+	237	WP_002457224.1	hypothetical protein	-
MNU37_RS09320 (MNU37_09310)	1974272..1974475	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU37_RS09325 (MNU37_09315)	1974884..1975141	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU37_RS09330 (MNU37_09320)	1975166..1975354	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU37_RS09335 (MNU37_09325)	1975544..1976098	+	555	WP_002469327.1	lipoprotein N-acylation protein LnsA	-
MNU37_RS09340 (MNU37_09330)	1976158..1976391	-	234	WP_001829664.1	hypothetical protein	-
MNU37_RS09345 (MNU37_09335)	1976675..1977421	+	747	WP_254105398.1	poly-gamma-glutamate hydrolase family protein	-
MNU37_RS09350 (MNU37_09340)	1977520..1977804	+	285	WP_001829635.1	hypothetical protein	-
MNU37_RS09355 (MNU37_09345)	1977828..1978052	+	225	WP_001829613.1	hypothetical protein	-
MNU37_RS09360 (MNU37_09350)	1978673..1978873	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1964359..1990135	25776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-80)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237774 WP_001829569.1 NZ_CP093193:1975166-1975354 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237774 NZ_LR882937:48017-48259 [Planktothrix agardhii]
TTGATTCAAAGCTTTGGCGATAAACGAACTGAGGATTTATTTCAAGGGATTTCTAATCGAGAAACTCGGAAATTTCCGGC
AGATTTAATTAAAGTAGCGGTGCGAAAACTGGATATGTTGAATGCGGCTTATCAATTGGAGGATTTACGTTCCCCACCGG
GCAATCGTTTAGAAGCTTTAAAAGGCGATTTAAAAGGCTTTTATAGTATCCGAATTAATGAGCAATGGCGGATTATTTTT
TAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237774 WP_002438963.1 NZ_CP093193:1974884-1975141 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237774 NZ_LR882937:48303-48539 [Planktothrix agardhii]
ATGATTAAATTATCTATGTTACCTCGAAATAGAATTCCAACTCATCCTGGGGAAATTTTATCGGAGGAATTTTTAATTCC
TTTAAGTTTAACTCAAGTGGCTTTAGCAGAACATTTGGGGGTTCCGGTACAACGAATTAATGAAATTGTTAAAGGAAAAC
GAGGGATAACACCGGAAACGGCTTGGTTATTCGCTCAAGCATTCCAAACCTCTCCTGAGTTTTGGATGAATTTATAA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3