Detailed information of TA system TA237773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1018117..1018919
• Replicon: chromosome
• Accession: NZ_CP093193
• Organism: Staphylococcus epidermidis strain TMDU-323

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: MNU37_RS04915
• Protein ID: WP_002468490.1
• Coordinates: 1018740..1018919 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MNU37_RS04910
• Protein ID: WP_002486232.1
• Coordinates: 1018117..1018716 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU37_RS04885 (MNU37_04880)	1013329..1014786	+	1458	WP_254105507.1	ABC transporter substrate-binding protein/permease	-
MNU37_RS04890 (MNU37_04885)	1014779..1015501	+	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
MNU37_RS04895 (MNU37_04890)	1015998..1016147	+	150	WP_002468809.1	hypothetical protein	-
MNU37_RS04900 (MNU37_04895)	1016362..1017492	+	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
MNU37_RS04905 (MNU37_04900)	1017489..1017959	+	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MNU37_RS04910 (MNU37_04905)	1018117..1018716	+	600	WP_002486232.1	glucosamine-6-phosphate isomerase	Antitoxin
MNU37_RS04915 (MNU37_04910)	1018740..1018919	+	180	WP_002468490.1	SAS053 family protein	Toxin
MNU37_RS04920 (MNU37_04915)	1019075..1019479	+	405	WP_002485605.1	hypothetical protein	-
MNU37_RS04925 (MNU37_04920)	1019664..1021049	+	1386	WP_001829862.1	class II fumarate hydratase	-
MNU37_RS04930 (MNU37_04925)	1021410..1022234	-	825	WP_001829804.1	RluA family pseudouridine synthase	-
MNU37_RS04935 (MNU37_04930)	1022393..1023526	+	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T237773 WP_002468490.1 NZ_CP093193:1018740-1018919 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T237773 NZ_LR882934:3976919-3977317 [Planktothrix agardhii]
GTGAAATTATTGTTGGATACCCAATGCTGGTTATGGTGGTTTGCCCAACCTGAGCGATTAAATCAGGAAGTGATCGCACA
GATTGCCGATGAAAGTAATGAATTATGGTTTTCTGTTGCTAGTGTTTGGGAAATTGGGATTAAAGTTGCGATCAGAAAAT
TACCATTACCAGAGCCAATAGATACCTACATTTCTAGTCGTATGGTGCAGTTAGATATGCGATATTTGGAAATCACAGCA
CCTCATGCACTGCGATCATCTGCGTTACCATTACATCATCGAGATCCCTTTGATCGTATGTTGATTGCTCAGGCTCAGAT
TGAGGATATGACGCTGGTAAGTGCTGATTCAATGTTCAAGCAATACAGCGATATTTCTGTTCTTTGGGCTGCTAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22695.55 Da
• Isoelectric Point: 4.8641

>AT237773 WP_002486232.1 NZ_CP093193:1018117-1018716 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT237773 NZ_LR882934:3976674-3976922 [Planktothrix agardhii]
ATTCAGATTGAAAACTTACCCAACGACTTCAAAAAAAATCTCTCTGAGTTATTGTCCCGTGTAGAACTTGGAGAAGAAAT
TATTATTTCCAATCAAGGGGTGGCGATCGCTAAGTTAATTCCGTTTCGTCCTTCATCCAATCGACGGGCGAGTTTAGGGC
AAGATCAAGGTAAATTTATCATACCAGATGACTTTAATGAACCGTTACCCCAAGAAATTTTGGCAGCATTTGAAGGAAAT
GAACAGTGA

Structures

Toxin

• AlphaFold DB: A0A2G7HY44