Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 859166..859695 Replicon chromosome
Accession NZ_CP093193
Organism Staphylococcus epidermidis strain TMDU-323

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU37_RS03980 Protein ID WP_001829891.1
Coordinates 859333..859695 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU37_RS03975 Protein ID WP_001829931.1
Coordinates 859166..859336 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU37_RS03950 (MNU37_03945) 854990..855469 + 480 WP_002457111.1 PH domain-containing protein -
MNU37_RS03955 (MNU37_03950) 855462..856967 + 1506 WP_002457110.1 PH domain-containing protein -
MNU37_RS03960 (MNU37_03955) 856954..857463 + 510 WP_002457109.1 PH domain-containing protein -
MNU37_RS03965 (MNU37_03960) 857511..857864 + 354 WP_002457108.1 holo-ACP synthase -
MNU37_RS03970 (MNU37_03965) 857931..859079 + 1149 WP_002457107.1 alanine racemase -
MNU37_RS03975 (MNU37_03970) 859166..859336 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU37_RS03980 (MNU37_03975) 859333..859695 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU37_RS03985 (MNU37_03980) 860040..861041 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU37_RS03990 (MNU37_03985) 861141..861467 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU37_RS03995 (MNU37_03990) 861469..861948 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU37_RS04000 (MNU37_03995) 861923..862693 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237772 WP_001829891.1 NZ_CP093193:859333-859695 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237772 NZ_LR882934:c3941725-3941471 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCCATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237772 WP_001829931.1 NZ_CP093193:859166-859336 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237772 NZ_LR882934:c3941478-3941329 [Planktothrix agardhii]
ATGAGTAACCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAGACTCT
CAAAAAAATTAATAAAATTATCAAAATTTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References