Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 847982..848491 Replicon chromosome
Accession NZ_CP093193
Organism Staphylococcus epidermidis strain TMDU-323

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU37_RS03920 Protein ID WP_001829980.1
Coordinates 848282..848491 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU37_RS03915 Protein ID WP_001829893.1
Coordinates 847982..848275 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU37_RS03890 (MNU37_03885) 842990..843778 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MNU37_RS03895 (MNU37_03890) 843784..844422 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU37_RS03900 (MNU37_03895) 844511..845383 + 873 WP_002470121.1 membrane protein insertase YidC -
MNU37_RS03905 (MNU37_03900) 845489..846142 - 654 WP_001829983.1 HD domain-containing protein -
MNU37_RS03910 (MNU37_03905) 846324..847808 - 1485 WP_002457116.1 cardiolipin synthase -
MNU37_RS03915 (MNU37_03910) 847982..848275 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU37_RS03920 (MNU37_03915) 848282..848491 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU37_RS03925 (MNU37_03920) 848634..848771 + 138 WP_001829949.1 Lmo0850 family protein -
MNU37_RS03930 (MNU37_03925) 848870..850081 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU37_RS03935 (MNU37_03930) 850472..851545 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MNU37_RS03940 (MNU37_03935) 851557..852912 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237771 WP_001829980.1 NZ_CP093193:848282-848491 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237771 NZ_LR882934:c3941478-3941329 [Planktothrix agardhii]
ATGAGTAACCGCATATTGGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAGACTCT
CAAAAAAATTAATAAAATTATCAAAATTTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237771 WP_001829893.1 NZ_CP093193:847982-848275 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237771 NZ_LR882934:c3941725-3941471 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCCATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References