Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2033183..2033653 Replicon chromosome
Accession NZ_CP093188
Organism Staphylococcus epidermidis strain TMDU-302

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MNU45_RS09635 Protein ID WP_001829569.1
Coordinates 2033465..2033653 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MNU45_RS09630 Protein ID WP_002438963.1
Coordinates 2033183..2033440 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU45_RS09590 (MNU45_09585) 2028547..2029263 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MNU45_RS09595 (MNU45_09590) 2029424..2029846 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MNU45_RS09600 (MNU45_09595) 2030030..2030167 - 138 WP_162161215.1 hypothetical protein -
MNU45_RS09605 (MNU45_09600) 2030197..2030384 - 188 Protein_1859 hypothetical protein -
MNU45_RS09610 (MNU45_09605) 2030771..2031271 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MNU45_RS09615 (MNU45_09610) 2031542..2032129 - 588 WP_001829615.1 histidine phosphatase family protein -
MNU45_RS09620 (MNU45_09615) 2032343..2032579 + 237 WP_002457224.1 hypothetical protein -
MNU45_RS09625 (MNU45_09620) 2032571..2032774 - 204 WP_001829671.1 sterile alpha motif-like domain-containing protein -
MNU45_RS09630 (MNU45_09625) 2033183..2033440 + 258 WP_002438963.1 hypothetical protein Antitoxin
MNU45_RS09635 (MNU45_09630) 2033465..2033653 + 189 WP_001829569.1 hypothetical protein Toxin
MNU45_RS09640 (MNU45_09635) 2033843..2034397 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MNU45_RS09645 (MNU45_09640) 2034457..2034690 - 234 WP_001829664.1 hypothetical protein -
MNU45_RS09650 (MNU45_09645) 2034975..2035721 + 747 WP_001829580.1 poly-gamma-glutamate hydrolase family protein -
MNU45_RS09655 (MNU45_09650) 2035820..2036104 + 285 WP_001829635.1 hypothetical protein -
MNU45_RS09660 (MNU45_09655) 2036128..2036352 + 225 WP_001829613.1 hypothetical protein -
MNU45_RS09665 (MNU45_09660) 2036973..2037173 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2024155..2051863 27708
- flank IS/Tn - - 2030030..2030185 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin

CopG antitoxin

(3-68)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T237770 WP_001829569.1 NZ_CP093188:2033465-2033653 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T237770 NZ_LR882934:c2162591-2162319 [Planktothrix agardhii]
ATGTATAGCTTTGAGTATGACGACAATAAAAGTCGAACCAACCAACAAAAACACGGCATAGACTTCATCGAAGCCCAACA
ACTTTGGCAAGACGATGACTTGTTGGAAATTCAGGCTACAAGCGAAACAGAATCGCGTTTTTTAGCCATTGGCAAACTGA
AGCAAAAACACTGGACAGCCGTTATCACTTACAGATTAGAAAATATCCGAATTATTTCCGTCCGCCGTTCCCGTCCCAAT
GAGGTTATATGGTATGAAAGCCGAAGAATTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT237770 WP_002438963.1 NZ_CP093188:2033183-2033440 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT237770 NZ_LR882934:c2162338-2162114 [Planktothrix agardhii]
ATGAAAGCCGAAGAATTTGACGCAAAATTTGACACAGGTGAAGACCTCACCGAATTTATGGATTTCTCGACCGCCAGACG
ACCCAACCGAGAAAAACAAAAAATAGAACTCAATTTACCCCTCTGGATGATTCGCCAACTCGAAGCCGAAGCTCAAAAAC
AGGGTATTTCTCCCCAAACCTTTTTAGAAAACTATTTAGCCGAAAATCTTGCCCCTGTTAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References