Detailed information of TA system TA023777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2316406..2317381
• Replicon: chromosome
• Accession: NC_012659
• Organism: Bacillus anthracis str. A0248

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A2R2IKP2
• Locus tag: BAA_RS12840
• Protein ID: WP_002036394.1
• Coordinates: 2316406..2317143 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: BAA_RS12845
• Protein ID: WP_000588712.1
• Coordinates: 2317256..2317381 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA_RS12820	2312134..2312916	+	783	WP_000381787.1	class I SAM-dependent methyltransferase	-
BAA_RS12825	2313038..2314723	-	1686	WP_009879073.1	alpha-keto acid decarboxylase family protein	-
BAA_RS12830	2314830..2315312	+	483	WP_000191911.1	MarR family winged helix-turn-helix transcriptional regulator	-
BAA_RS12835	2315480..2316217	+	738	WP_000594139.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BAA_RS12840	2316406..2317143	+	738	WP_002036394.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BAA_RS12845	2317256..2317381	+	126	WP_000588712.1	hypothetical protein	Antitoxin
BAA_RS32095	2317458..2317634	+	177	WP_000852614.1	hypothetical protein	-
BAA_RS12855	2317671..2317952	-	282	WP_001041555.1	hypothetical protein	-
BAA_RS12860	2318229..2318465	-	237	WP_001021689.1	hypothetical protein	-
BAA_RS32100	2318804..2318980	+	177	WP_000808045.1	hypothetical protein	-
BAA_RS12870	2319124..2320593	+	1470	WP_000287522.1	beta-Ala-His dipeptidase	-
BAA_RS12875	2321157..2321627	-	471	WP_000670597.1	DUF5065 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28373.03 Da
• Isoelectric Point: 8.2705

>T23777 WP_002036394.1 NC_012659:2316406-2317143 [Bacillus anthracis str. A0248]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T23777 NC_012659:2316406-2317143 [Bacillus anthracis str. A0248]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT23777 WP_000588712.1 NC_012659:2317256-2317381 [Bacillus anthracis str. A0248]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT23777 NC_012659:2317256-2317381 [Bacillus anthracis str. A0248]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A2R2IKP2

Antitoxin

• AlphaFold DB: A0A366GQT1